7-Hydroxyquinoline synthesis
- Product Name:7-Hydroxyquinoline
- CAS Number:580-20-1
- Molecular formula:C9H7NO
- Molecular Weight:145.16
4965-36-0
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580-20-1
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Yield: 78%
Reaction Conditions:
with copper(I) oxide;1D-1-O-Methyl-muco-inostol;sodium hydroxide in water at 130; for 6 h;
Steps:
19 Example 19: Preparation of 7-hydroxyquinoline:
In the l00mL hydrothermal synthesis reactor,Add sodium hydroxide (3 mmol), water (5 mL), stir and dissolve,Add 7-bromoquinoline (0.5 mmol), cuprous oxide (0.05 mmol),White hardwood alcohol (0.05 mmol), the reaction was stirred evenly at 130 ° C for 6 hours.After cooling, the pH was adjusted to 8 with dilute hydrochloric acid and extracted with ethyl acetate.The extract is concentrated and subjected to column chromatography to give 7-hydroxyquinoline, 57.3 mg.The yield was 78%.
References:
Shenyang Pharmaceutical University;Yunnan Tropical Crop Science Institute;Chen Guoliang;Wu Ying;Bao Xuefei;Li Guohua;Liang Xinjie;Jiang Shikuan;Zhou Qifan;Du Fangyu CN109970542, 2019, A Location in patent:Paragraph 0090-0092
![7-Quinolinol, 1,2-dihydro-1-[(4-methylphenyl)sulfonyl]-](/CAS/20200331/GIF/333383-93-0.gif)
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580-20-1
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58196-33-1
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3054-95-3
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591-27-5
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