TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE synthesis
- Product Name:TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE
- CAS Number:635698-56-5
- Molecular formula:C12H15Cl2N3O2
- Molecular Weight:304.17
![2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride](/CAS2/GIF/1208901-69-2.gif)
1208901-69-2
53 suppliers
$38.00/100mg
24424-99-5
861 suppliers
$13.50/25G
635698-56-5
134 suppliers
$24.00/100mg
Yield: 100%
Reaction Conditions:
with triethylamine in dichloromethane at 20; for 0.333333 h;Product distribution / selectivity;
Steps:
4.1
2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride prepared according to Reference Example 1 (2.00 g) and triethylamine (2.80 mL, 2.4 equivalents) were dissolved in dichloromethane (40 mL), and the solution was mixed with di-tert-butyl dicarbonate (2.29 mL, 1.2 equivalents), followed by stirring at room temperature for twenty minutes. The reaction mixture was sequentially washed with water, a saturated aqueous sodium bicarbonate solution and brine, followed by extraction with chloroform. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off, to thereby yield tert-butyl 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-6-car boxylate (3.0g, in a quantitative yield).
References:
KYOWA HAKKO KOGYO CO., LTD. EP1552842, 2005, A1 Location in patent:Page/Page column 316
![2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE](/CAS/GIF/726697-13-8.gif)
726697-13-8
37 suppliers
$312.00/250mg
24424-99-5
861 suppliers
$13.50/25G
635698-56-5
134 suppliers
$24.00/100mg
![6-BENZYL-2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE](/CAS/GIF/778574-06-4.gif)
778574-06-4
120 suppliers
$104.00/1g
635698-56-5
134 suppliers
$24.00/100mg
![6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE](/CAS/GIF/135481-57-1.gif)
135481-57-1
82 suppliers
$18.00/250mg
635698-56-5
134 suppliers
$24.00/100mg
57611-47-9
0 suppliers
$47.00/1g
635698-56-5
134 suppliers
$24.00/100mg