6-Bromoquinoxaline synthesis
- Product Name:6-Bromoquinoxaline
- CAS Number:50998-17-9
- Molecular formula:C8H5BrN2
- Molecular Weight:209.04
91-19-0
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$20.00/25g
50998-17-9
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$6.00/250mg
Yield:50998-17-9 50%
Reaction Conditions:
with N-Bromosuccinimide;dibenzoyl peroxide in acetic acid for 20 h;Reflux;Inert atmosphere;Reagent/catalyst;Solvent;
Steps:
4.7. Bromination of quinoxaline (1) with NBS in AcOH or DMF
A solution of quinoxaline (1) (390mg, 3.0mmol), NBS (390mg, 3.0mmol), and benzoyl peroxide (catalytic amount) in glacial acetic acid (10mL) was heated at reflux temperature for 20h. The reaction was monitored by TLC or 1H NMR spectroscopy. The resulting reaction mixture was allowed to cool to room temperature and the solvent was removed under reduced pressure. The mixture was diluted with a saturated solution of sodium carbonate (10mL) and the mixture was extracted with ethyl acetate (2×25mL). Combined organic layers were washed with water, dried over Na2SO4 and concentrated. 6-Bromoquinoxaline (10) (315mg, 50%) was obtained as a sole product. The reaction was repeated using DMF as a solvent at the same reaction condition and monobromide 10 was obtained in 51% yield.
References:
U?ar, Sefa;E?siz, Sel?uk;Da?tan, Arif [Tetrahedron,2017,vol. 73,# 12,p. 1618 - 1632]
89980-70-1
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50998-17-9
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$6.00/250mg
131543-46-9
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1575-37-7
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$10.00/1g
50998-17-9
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$6.00/250mg
107-21-1
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1575-37-7
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50998-17-9
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3476-89-9
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50998-17-9
194 suppliers
$6.00/250mg