1-[2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOL-5-YL]-1-ETHANONE synthesis
- Product Name:1-[2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOL-5-YL]-1-ETHANONE
- CAS Number:54001-07-9
- Molecular formula:C12H10ClNOS
- Molecular Weight:251.73
1694-29-7
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54001-07-9
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Yield:54001-07-9 90%
Reaction Conditions:
in ethanol; for 8 h;
Steps:
4.1.1. General synthesis of 1-(4-methyl-2-(40-substitutedphenylthiazole-5-yl)ethane-1-one derivatives (methodA)
General procedure: According to the Hantzsch method, 3-chloro-2,4-pentandione isadded to the hot solution of aryl thioamide in absolute ethanol(Scheme 1) and boiled for 8 h. After being controlled with TLCwhere the reaction is completed, itwas left to cool, poured into coldwater and neutralized by sodium acetate solution. After the precipiationwas completed, it is taken and dried, crystallized fromethanol [40].
References:
Sahin, Zafer;Biltekin, Sevde Nur;Yurttas, Leyla;Berk, Barkin;?zhan, Ya?mur;Sipahi, Hande;Gao, Zhan-Guo;Jacobson, Kenneth A.;Demirayak, ?eref [European Journal of Medicinal Chemistry,2021,vol. 212,art. no. 113125]
![2,4-Pentanedione, 3-[[(4-methylphenyl)sulfonyl]oxy]-](/CAS/20180601/GIF/81447-35-0.gif)
81447-35-0
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2521-24-6
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54001-07-9
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$181.00/500mg
3043-28-5
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54001-07-9
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![Ethanone, 1-[2-(4-chlorophenyl)-4-methyl-5-thiazolyl]-2-diazo-](/CAS/20211123/GIF/54001-29-5.gif)
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54001-07-9
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$181.00/500mg
54001-22-8
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54001-07-9
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$181.00/500mg