3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid synthesis
- Product Name:3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid
- CAS Number:500011-86-9
- Molecular formula:C9H5BrClN3O2
- Molecular Weight:302.51
500011-92-7
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500011-86-9
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Yield:500011-86-9 92%
Reaction Conditions:
with water;sodium hydroxide in methanol at 20; for 5.5 h;
Steps:
1.5 Example 1
32 g of ethyl 3-bromo-1- (3-chloropyridin-2-yl) -1H-pyrazole-5-carboxylate was added to the reaction flask,Sodium hydroxide 5.5g,Methanol (110 ml) and water (100 ml)Stirring reaction at room temperature 5.5h,Methanol was distilled off under reduced pressure,The organic layer was extracted with ether,The aqueous phase was acidified with concentrated hydrochloric acid to pH = 2,There is a fixed precipitation,filter,Dried to give 1- (3-chloropyridin-2-yl) -3-bromo-1H-pyrazole-5-carboxylic acid.
References:
Nantong Yaben Chemical Co., Ltd.;Lv, Jian;Niu, Yuehui;Wu, Zhengguang CN106187998, 2016, A Location in patent:Paragraph 0009; 0012
500011-85-8
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124-38-9
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500011-86-9
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$8.00/250mg
1045077-26-6
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500011-86-9
172 suppliers
$8.00/250mg
500011-85-8
5 suppliers
$210.25/1g
500011-86-9
172 suppliers
$8.00/250mg
697799-65-8
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500011-86-9
172 suppliers
$8.00/250mg