5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID synthesis
- Product Name:5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID
- CAS Number:58483-95-7
- Molecular formula:C6H5ClN2O2
- Molecular Weight:172.57
![5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID](/CAS/GIF/171178-46-4.gif)
171178-46-4
55 suppliers
$51.00/250mg
58483-95-7
151 suppliers
$12.00/250mg
Yield:58483-95-7 87%
Reaction Conditions:
with trifluoroacetic acid in dichloromethane
Steps:
58 4-(3-Bromoanilino)-6-chloropyrido[3,4-d]pyrimidine
5-Amino-2-chloropyridine-4-carboxylic acid. A stirred suspension of 5-[N-(tert-butoxycarbonyl)amino]-2-chloropyridine-4-carboxylic acid (1.91 g, 7 mmol) in CH2 Cl2 (200 mL) is treated slowly with trifluoroacetic acid until homogeneous (ca. 12 mL). The solution is stirred overnight and extracted with dilute NH4 OH, and the aqueous layer is then acidified with dilute HCl to gave a precipitate of 5-amino-2-chloropyridine-4-carboxylic acid (1.05 g, 87% yield). 1 H NMR (DMSO) δ 9.01 (2H, m), 8.03 (1H, s), 7.48 (1H, s).
References:
Warner-Lambert Company US5654307, 1997, A
![5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE](/CAS/GIF/171178-45-3.gif)
171178-45-3
135 suppliers
$8.00/250mg
58483-95-7
151 suppliers
$12.00/250mg
5350-93-6
430 suppliers
$6.00/5g
58483-95-7
151 suppliers
$12.00/250mg
1072-98-6
713 suppliers
$5.00/1g
58483-95-7
151 suppliers
$12.00/250mg
5326-23-8
569 suppliers
$5.00/1g
58483-95-7
151 suppliers
$12.00/250mg