4-Iodo-1-methyl-1H-imidazole synthesis
- Product Name:4-Iodo-1-methyl-1H-imidazole
- CAS Number:71759-87-0
- Molecular formula:C4H5IN2
- Molecular Weight:208
37067-96-2
60 suppliers
$53.02/1gm:
71759-87-0
196 suppliers
$53.00/1 g
Yield:71759-87-0 94%
Reaction Conditions:
with ethylmagnesium bromide in diethyl ether;dichloromethane at 20; for 0.333333 h;
Steps:
4.1. 4-Iodo-1-methyl-1H-imidazole (15)
EtMgBr (3.0 M solution in ether, 11.00 mL, 32.9 mmol) wasadded to a solution of 14 (10.00 g, 29.9 mmol) in dry CH2Cl2(150 mL) at rt. over 15 min. The resulting mixture was stirredfor 20 min and water (20 mL) was added to the reaction mixtureafter running a TLC experiment to confirm all the starting materialis consumed. Then, the layers were separated. The aqueous layerwas extracted with CH2Cl2 (3 50 mL) and the combined organiclayers were dried (Na2SO4) and concentrated to isolate 15 as paleyellow oil (5.86 g, 94%).
References:
Koswatta, Panduka B.;Kasiri, Sabha;Das, Jayanta K.;Bhan, Arunoday;Lima, Heather M.;Garcia-Barboza, Beatriz;Khatibi, Nicole N.;Yousufuddin, Muhammed;Mandal, Subhrangsu S.;Lovely, Carl J. [Bioorganic and Medicinal Chemistry,2017,vol. 25,# 5,p. 1608 - 1621]
71759-89-2
433 suppliers
$6.00/1g
74-88-4
355 suppliers
$15.00/10g
71759-87-0
196 suppliers
$53.00/1 g
71759-89-2
433 suppliers
$6.00/1g
74-88-4
355 suppliers
$15.00/10g
71759-87-0
196 suppliers
$53.00/1 g
71759-88-1
118 suppliers
$50.10/250mg
77-78-1
327 suppliers
$19.69/1ml
71759-89-2
433 suppliers
$6.00/1g
71759-87-0
196 suppliers
$53.00/1 g
71759-88-1
118 suppliers
$50.10/250mg