4-FLUORO-3-METHOXYBENZALDEHYDE synthesis
- Product Name:4-FLUORO-3-METHOXYBENZALDEHYDE
- CAS Number:128495-46-5
- Molecular formula:C8H7FO2
- Molecular Weight:154.14
128495-45-4
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128495-46-5
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Yield:128495-46-5 85%
Reaction Conditions:
with manganese(IV) oxide in dichloromethane; for 16 h;Heating / reflux;
Steps:
16 EXAMPLE 16; 4-FLUORO-3-METHOXYBENZALDEHYDE
(4-FLUORO-3-METHOXYPHENYL) METHANOL (5. 00G, 0. 03mol) and manganese dioxide (33.4g, 0. 38MOL) were stirred in DICHLOROMETHANE (100ml) under an atmosphere of nitrogen, at gentle reflux for 16 hours. The cooled reaction mixture was then filtered through arbacel and concentrated in vacuo to give the title compound as a white solid (4.18g, 0. 027MOL, 85%). 1H NMR (CDCI3, 400MHZ) 8 : 3.96 (s, 3H), 7.23 (d, 1H), 7.43 (m, 1 H), 7.50 (d, 1 H) 9.91 (s, 1H). Mpt: 61-63°C. Analysis found C, 62.18 ; H, 4.54%. C8H7FO2 requires C, 62.34 ; H, 4.58%.
References:
WO2004/52372,2004,A1 Location in patent:Page 72
194018-68-3
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82846-18-2
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63762-78-7
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63762-79-8
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128495-46-5
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