天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 4-Cyano-3-fluorobenzoic acid
176508-81-9

4-Cyano-3-fluorobenzoic acid synthesis

5synthesis methods
-

Yield:-

Reaction Conditions:

tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide at 90; for 3 h;

Steps:

1.A
4-Cyano-3-fluorobenzoic acid: 4-Bromo-3-fluorobenzoic acid(7.5 g, 0.034 mol), Zn(CN)2 (4.0 g, 0.034 mol) and Pd(PPh3)4 (3.95 g, 0.0034 mol) were added together with 60 mL of DMF (degassed). The mixture was heated at 90 0C under N2 for 3 h. It was cooled to room temperature and filtered to remove insoluble inorganic salts (discarded). The filtrate was diluted with water and extracted with EtOAc. The EtOAc mixture was washed with water, brine, dried over MgSO4, and concentrated to yield 4.5 g of the desired product with 90% purity. This material was taken into the next step without further purification. 1H-NMR (500 MHz, d4-Me0H) δ 7.82 (m, IH), 7.90 (m, 3H), 7.56 (d, J= 10.0 Hz, IH), 7.68 (s, IH), 7.96 (d, J= 8.4 Hz, IH)

References:

BRISTOL-MYERS SQUIBB COMPANY WO2007/70826, 2007, A1 Location in patent:Page/Page column 121

201230-82-2 Synthesis
carbon monoxide

201230-82-2
1 suppliers
inquiry

105942-08-3 Synthesis
4-Bromo-2-fluorobenzonitrile

105942-08-3
381 suppliers
$7.00/5g

4-Cyano-3-fluorobenzoic acid Related Search: