4-CHLOROBENZOYL ISOTHIOCYANATE synthesis
- Product Name:4-CHLOROBENZOYL ISOTHIOCYANATE
- CAS Number:16794-67-5
- Molecular formula:C8H4ClNOS
- Molecular Weight:197.64
333-20-0
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Yield: 90%
Reaction Conditions:
Stage #1:para-chlorobenzoic acid with trichloroisocyanuric acid;triphenylphosphine in toluene at 0; for 0.25 h;
Stage #2:potassium thioacyanate in toluene at 0 - 20; for 0.583333 h;
Steps:
Preparation of Benzoyl Isothiocyanate from Benzoic Acid
General procedure: To a cold solution of triphenylphosphine (0.262 g, 1 mmol) in toluene (3 mL), trichloroisocyanuric acid (0.069 g, 0.3 mmol) was added with continuous stirring. Benzoic acid (0.097 g, 0.8 mmol) was added and stirring was continued for 15 min. Potassium thiocyanate (0.193 g, 2 mmol) was added and the temperature was raised up to room temperature. Stirring was continued for 40 min at room temperature. The progress of the reaction was followed by TLC. Upon completion of the reaction, the concentrated residue passed through a short silica gel column using n-hexane / ethyl acetate mixture (vol. ratio: 60:1) as the eluent. Benzoyl isothiocyanate was obtained with 95 % yield after removing the solvent under reduced pressure.
References:
Entezari, Najmeh;Akhlaghinia, Batool;Rouhi-Saadabad, Hamed [Croatica Chemica Acta,2014,vol. 87,# 3,p. 201 - 206]
333-20-0
459 suppliers
$13.50/100G
122-01-0
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$13.00/25g
16794-67-5
55 suppliers
$45.00/50mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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122-01-0
384 suppliers
$13.00/25g
16794-67-5
55 suppliers
$45.00/50mg
122-01-0
384 suppliers
$13.00/25g
16794-67-5
55 suppliers
$45.00/50mg