4,6-Dihydroxy-5-formylpyrimidine synthesis
- Product Name:4,6-Dihydroxy-5-formylpyrimidine
- CAS Number:14256-99-6
- Molecular formula:C5H4N2O3
- Molecular Weight:140.1
15263-75-9
14256-99-6
The general procedure for the synthesis of 4,6-dihydroxy-5-formylpyrimidines from N-((4-hydroxy-6-oxo-1,6-dihydropyrimidin-5-yl)methylene)-N-methylmethylammonium chloride was as follows: 30 mL of water was added to the reaction flask and stirring was initiated. The temperature of the reaction system was raised to 20-30 °C, followed by the addition of N-((4,6-dihydroxypyrimidin-5-yl)methylene)-N-methylmethylammonium chloride salt (10.0 g, 49.11 mmol). The reaction was kept at this temperature for 18 hours. After completion of the reaction, 50 mL of anhydrous ethanol was added to the mixture and stirring was continued. The reaction mixture was filtered and the resulting filter cake was washed with a small amount of anhydrous ethanol. Finally, the product was dried under vacuum at 40-45 °C to give 5.77 g of yellow solid.
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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Yield: 5.77 g
Reaction Conditions:
with water at 20 - 30; for 18 h;
Steps:
2.3 Synthesis of 4,6-dihydroxypyrimidine-5-carboxaldehyde
Add water (30ml) to the reaction flask and stir.Warm up to 20-30 ° C,Add N-((4,6-dihydroxypyrimidin-5-yl)methylene)-N-methylmethylammonium chloride salt (10.0 g, 49.11 mmol) at 20-30 °C.Reaction at 20-30 ° C for 18 hours,50 ml of absolute ethanol was added to the reaction mixture, stirred, filtered, and the filter cake was washed with a small amount of anhydrous ethanol.Drain,Drying in vacuo at 40-45 ° C gave 5.77 g of a yellow solid.
References:
He Ji Whampoa Pharmaceutical (Shanghai) Co., Ltd.;Liu Bo;Zhang Bin;Yan Huixin;Ge Chongfeng CN108178748, 2018, A Location in patent:Paragraph 0051; 0052; 0063-0065