4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE synthesis
- Product Name:4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE
- CAS Number:145783-14-8
- Molecular formula:C7H7Cl2N3O2S
- Molecular Weight:268.12
145783-13-7
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145783-14-8
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Yield:145783-14-8 93%
Reaction Conditions:
with phosgene in N,N-dimethyl-formamide at 0 - 20; for 16 h;
Steps:
2 Example 2 - with DMF
50 g (216.2 mmol, 1 eq) of compound of formula (1) were dissolved in 250 mL of DMF. 1000 mL of DMF were mixed with 47 g of phosgene (475.6 mmol, 2.2 eq) at 0°C. The solution of compound of formula (1) was added to the mixture of DMF with phosgene at 0°C. After 14 h stirring at 0°C and then 2 h at RT, 500 mL of water and 500 mL of toluene were added at 0°C. The mixture was stirred 30 min and the phases were separated. The organic phase was evaporated under vacuum. 54 g of compound of formula (2) were isolated (93% yield, 98.4% purity, GC analysis showed 1.1% of compound of formula (3), 0.26% of compound of formula (4) and 0.24% of compound of formula (5)).
References:
LONZA LTD;BERSIER, Michael;HANSELMANN, Paul;STOFFEL, Candid WO2019/16111, 2019, A1 Location in patent:Page/Page column 10
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145783-14-8
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121-69-7
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145783-14-8
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145783-14-8
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