METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER synthesis
- Product Name:METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER
- CAS Number:392338-15-7
- Molecular formula:C10H20N2O2
- Molecular Weight:200.28
![Carbamic acid, N-methyl-N-[(3R)-1-(phenylmethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/762286-32-8.gif)
762286-32-8
0 suppliers
inquiry
392338-15-7
106 suppliers
$45.00/50mg
Yield:392338-15-7 100%
Reaction Conditions:
with ammonium formate;palladium 10% on activated carbon in methanol;water; for 5 h;Heating / reflux;
Steps:
5.b
(b) Title compoundA solution of the compound obtained above (14.5 g, 50.14 mmol), Pd/C (10%, 50% in water) (3g) and ammonium formate (12.7 g, 200.5 mmol) in a mixture of MeOH (390 ml_) and water (45 ml_) was heated at reflux for 5 hours. The reaction was filtered through Celite and the filtrate was washed with AcOEt and MeOH. The solvent was evaporated to dryness to afford 10.6 g of the title compound as an oil(yield: 100%).1H NMR (300 MHz, CDCI3) δ: 1.38 (s, 9H), 1.72 (m, 1 H), 1.96 (m, 1 H), 2.53 (s, NH), 2.80 (s, 3H), 2.87 (m, 1 H), 2.93 (m, 1 H), 3.11 (m, 2H), 4.58 (m, 1 H).
References:
WO2007/31529,2007,A1 Location in patent:Page/Page column 24
![benzyl (3R)-3-[(tert-butoxycarbonyl)(methyl)amino]pyrrolidine-1-carboxylate](/CAS/20180808/GIF/638217-49-9.gif)
638217-49-9
4 suppliers
inquiry
392338-15-7
106 suppliers
$45.00/50mg
24424-99-5
861 suppliers
$13.50/25G
392338-15-7
106 suppliers
$45.00/50mg
144043-17-4
59 suppliers
$45.00/100mg
392338-15-7
106 suppliers
$45.00/50mg