3'-(Trifluoromethyl)acetophenone synthesis
- Product Name:3'-(Trifluoromethyl)acetophenone
- CAS Number:349-76-8
- Molecular formula:C9H7F3O
- Molecular Weight:188.15
Yield:349-76-8 96.3%
Reaction Conditions:
with tetrabutylammonium bromide;sodium tertiary butoxide at 65 - 75; under 3750.38 - 4500.45 Torr; for 9 h;Inert atmosphere;Large scale;Green chemistry;Reagent/catalyst;Temperature;Pressure;
Steps:
1-10 Example 4
In the 8000l stainless steel reaction kettle, drop into 4000kg of ethyl n-propyl ether, 1000kg of trifluoromethylbenzene, 472kg of acetic acid, 30kg of tetrabutylammonium bromide, 6kg of sodium tert-butoxide, pressurized with nitrogen gas 0.5-0.6MPa, and heated up with stirring. Reaction at 65-75°C for 9 hours,Cool to normal temperature, add 300kg of water for washing, stand for stratification, separate the water phase, and the oil phase is subjected to vacuum distillation to remove ethyl n-propyl ether,The weight of m-trifluoromethyl acetophenone is 1232 kg, the content is 99.6%, and the yield is 96.3% in terms of trifluoromethyl benzene.
References:
CN113956143,2022,A Location in patent:Paragraph 0035-0054
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