3-PHENYL-4-PICOLINE synthesis
- Product Name:3-PHENYL-4-PICOLINE
- CAS Number:19352-29-5
- Molecular formula:C12H11N
- Molecular Weight:169.22
72093-04-0
100-58-3
19352-29-5
Pd Catalyst 1 (12.6 mg, 0.045 mmol, calculated based on the molar concentration of Pd) and 3-chloro-4-methylpyridine (0.2 mmol) were added to a Schlenk tube equipped with a magnetic stir bar. Anhydrous toluene (2.0 mL) and phenylmagnesium bromide (0.3 mmol, 1.5 equiv) were added sequentially under nitrogen protection. The reaction mixture was heated to 140 °C and the reaction was stirred at this temperature until complete consumption of 3-chloro-4-methylpyridine was confirmed by thin layer chromatography (TLC) monitoring. Upon completion of the reaction, the reaction mixture was purified by silica gel column chromatography to afford the target product 3-phenyl-4-methylpyridine.
72093-04-0
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98-80-6
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19352-29-5
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$57.00/100mg
Yield:19352-29-5 92%
Reaction Conditions:
with 4,5-dimethyl-3-(2-phenoxyphenyl)-1-(2,4,6-trimethylbenzyl)imidazolium chloride;palladium diacetate;caesium carbonate in 1,4-dioxane at 90; for 18 h;Inert atmosphere;Suzuki-Miyaura Coupling;
References:
Kuriyama, Masami;Matsuo, Seira;Shinozawa, Mina;Onomura, Osamu [Organic Letters,2013,vol. 15,# 11,p. 2716 - 2719] Location in patent:supporting information
72093-04-0
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100-58-3
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19352-29-5
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$57.00/100mg
3430-22-6
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98-80-6
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$5.00/5g
19352-29-5
45 suppliers
$57.00/100mg
24388-23-6
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3430-22-6
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19352-29-5
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$57.00/100mg
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19352-29-5
45 suppliers
$57.00/100mg