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695-88-5

3-Methylquinuclidine synthesis

5synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 - 45 °C / Inert atmosphere
1.2: 4 h / 20 °C / Inert atmosphere; Reflux
2.1: hydrogen; platinum(IV) oxide / ethanol / 3 h / 20 °C

References:

Yang, Chen-Kai;Chen, Wang-Nan;Ding, Yan-Ting;Wang, Jing;Rao, Yin;Liao, Wei-Qiang;Xie, Yongfa;Zou, Wennan;Xiong, Ren-Gen [Journal of the American Chemical Society,2019,vol. 141,# 4,p. 1781 - 1787]