(3-METHYL-PYRIDIN-2-YL)-THIOUREA synthesis
- Product Name:(3-METHYL-PYRIDIN-2-YL)-THIOUREA
- CAS Number:21242-21-7
- Molecular formula:C7H9N3S
- Molecular Weight:167.23
![Benzamide, N-[[(4-methyl-2-pyridinyl)amino]thioxomethyl]-](/CAS/20210305/GIF/35798-55-1.gif)
35798-55-1
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21242-21-7
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Yield:21242-21-7 81%
Reaction Conditions:
with water;sodium hydroxide in methanol; for 1 h;Reflux;
Steps:
1-(4-Methylpyridin-2-yl)thiourea (1)
Compound 1 was synthesized by adapting a literature protocol[18]. 7.4 mL of 1 N aqueous NaOH were added to a stirred suspension of 1-benzoyl-3-(4-methylpyridin-2-yl)thiourea(2.00 g, 7.37 mmol) in 15 mL of methanol. The mixture was then heated to reflux for 1 h. After cooling to room temperature, a white solid formed, which was separated byfiltration, washed with deionized water and dried over P2O5in a vacuum desiccator to yield 1.00 g of 1 (5.98 mmol,81%). Physical properties were in agreement with thosereported in the literature [19]. Crystals of 1α suitable forX-ray diffraction were obtained by recrystallization from methanol, and those of 1β were grown from a solution in CDCl3by slow evaporation of the solvent.
References:
B?ck, Denise;Beuchel, Andreas;Goddard, Richard;Imming, Peter;Seidel, Rüdiger W. [Journal of Chemical Crystallography,2021,vol. 51,# 3,p. 394 - 404]
695-34-1
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532-55-8
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21242-21-7
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$29.00/250mg
53385-81-2
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21242-21-7
44 suppliers
$29.00/250mg
695-34-1
545 suppliers
$5.00/10g
21242-21-7
44 suppliers
$29.00/250mg