3-Chlorophenol synthesis
- Product Name:3-Chlorophenol
- CAS Number:108-43-0
- Molecular formula:C6H5ClO
- Molecular Weight:128.56
24318-02-3
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108-43-0
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Yield:108-43-0 99%
Reaction Conditions:
with 1-n-butyl-3-methylimidazolim bromide at 200 - 220; for 0.0833333 h;Microwave irradiation;Inert atmosphere;
Steps:
2. Preparation of phenolic compounds
General procedure: To a microwave tube was added alkyl aryl ether (1.0 mmol) and 1-n-butyl-3-methylimidazolium bromide (0.65 g, 3.0 mmol). The reaction tube was flushed with argon and then was irradiated at 20 W for the designated time period with air-flow cooling to prevent overheating (power control mode). After cooled to room temperature, the reaction mixture was acidified with 1 NHCl solution and extracted with ethyl acetate (3 × 15 mL). The combined organic layer was washed with water and brine, and dried over anhydrous MgSO4 and the solvent was evaporated under vacuum. Purification of the crude product by column chromatography (ethyl acetate in n-hexane)afforded the desired product.
References:
Park, Se Kyung;Battsengel, Oyunsaikhan;Chae, Junghyun [Bulletin of the Korean Chemical Society,2013,vol. 34,# 1,p. 174 - 178] Location in patent:supporting information
625-99-0
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108-43-0
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63503-60-6
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108-43-0
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108-42-9
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108-43-0
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1005-41-0
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108-43-0
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$13.00/5g