3-BROMO-2-METHYLIMIDAZO[1,2-A]PYRIDINE synthesis
- Product Name:3-BROMO-2-METHYLIMIDAZO[1,2-A]PYRIDINE
- CAS Number:4805-70-3
- Molecular formula:C8H7BrN2
- Molecular Weight:211.06
![2-Methylimidazo[1,2-a]pyridine](/CAS/GIF/934-37-2.gif)
934-37-2
79 suppliers
$25.00/250mg
4805-70-3
43 suppliers
$61.00/250mg
Yield:4805-70-3 95%
Reaction Conditions:
with anhydrous sodium carbonate;pyridinium hydrobromide perbromide in N,N-dimethyl-formamide at 25 - 43; for 0.5 h;Sonication;Schlenk technique;Green chemistry;regioselective reaction;
Steps:
3-Bromo-2-phenylimidazo[1,2-a]pyridine (3a); Typical Procedure
General procedure: A mixture of 2-phenylimidazo[1,2-a]pyridine (1a; 38.8 mg, 0.20 mmol), pyridinium tribromide (2a; 63.9 mg, 0.20 mmol) and Na2CO3 (21.2 mg, 0.2 mmol) in DMF (2.0 mL) in a Schlenk tube at r.t. was subjected to ultrasonic irradiation JP-120ST(Skymen) for 30 min. After the reaction was complete, the mixture was extracted with EtOAc (3 5 mL). The combined organic extracts were washed with brine (10 mL), dried over Na2SO4 and filtered. The solvent was removed under reduced pressure and the residue was purified by flash column chromatography (silica gel, 200-300 mesh) to give desired product 3a.
References:
Jiang, Hongmei;Guo, Dingyi;Zhang, Yixin;Shen, Qin-Peng;Tang, Shiyun;You, Junheng;Huo, Yi;Wang, Huixian;Gui, Qing-Wen [Synthesis,2020,vol. 52,# 18,p. 2713 - 2720]
504-29-0
560 suppliers
$5.00/5G
598-31-2
120 suppliers
$60.00/50mg
4805-70-3
43 suppliers
$61.00/250mg
504-29-0
560 suppliers
$5.00/5G
4805-70-3
43 suppliers
$61.00/250mg
![IMidazo[1,2-a]pyridine,2-chloro-](/CAS/GIF/3999-05-1.gif)
3999-05-1
51 suppliers
$159.58/250mg
4805-70-3
43 suppliers
$61.00/250mg
![2-Iodoimidazo[1,2-a]pyridine](/CAS/GIF/1373338-15-8.gif)
1373338-15-8
5 suppliers
inquiry
4805-70-3
43 suppliers
$61.00/250mg