ChemicalBook CAS DataBase List 3-AMINO-2-CYCLOHEXEN-1-ONE

3-AMINO-2-CYCLOHEXEN-1-ONE synthesis

7synthesis methods

Product Name:3-AMINO-2-CYCLOHEXEN-1-ONE
CAS Number:5220-49-5
Molecular formula:C6H9NO
Molecular Weight:111.14

504-02-9

5220-49-5

General procedure for the synthesis of 3-amino-2-cyclohexen-1-one from 1,3-cyclohexanedione: 1,3-cyclohexanedione (0.03 mol) and ammonium acetate (0.039 mol) were added to a 100 mL three-necked flask, and the mixture was thoroughly stirred. The mixture was placed in an oil bath at 110°C for 15 min of reaction. Upon completion of the reaction, the oil bath was removed and the reaction system was allowed to cool naturally, at which time the reaction solution gradually solidified. After cooling to room temperature, ethyl acetate (10 mL) was added to the reaction mixture and heated to dissolve the solid, which was subsequently cooled to 0°C to promote crystallization. The precipitated solid was collected by filtration and dried to give yellow crystals of 3-amino-2-cyclohexen-1-one in 93.6% yield.

504-02-9 Synthesis

504-02-9
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5220-49-5
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Yield:5220-49-5 93.6%

Reaction Conditions:

with ammonium acetate at 110; for 0.25 h;Temperature;

Steps:

3.a Step a: Preparation of 3-amino-2-cyclohexenone
The 1,3-cyclohexanedione (0 · 03mol) and ammonium acetate (0 · 039mol) added to 100ml three-necked flask, stir hook, the reaction conditions in an oil bath at 110 °C 15min, Remove the oil bath and then naturally cool,During which the reaction liquid is solidified. After cooling to room temperature, ethyl acetate (10 ml) is added, heated to dissolve and cooled to 0 °C., filtered and the filter cake is dried to obtain yellow crystals of 3-amino-2-cyclohexenone (Yield 93.6%)

References:

Shenzhen Ruilin Pharmaceutical Co., Ltd.;Zhang Jing;Fang Zihua;Liu Fenghua;Yang Ling CN107337639, 2017, A Location in patent:Paragraph 0120; 0123; 0135; 0144-0146; 0157; 0168; 0179

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591-27-5 Synthesis