2-(CHLOROMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE synthesis
- Product Name:2-(CHLOROMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE
- CAS Number:2164-33-2
- Molecular formula:C9H9ClO2
- Molecular Weight:184.62
3663-82-9
146 suppliers
$13.43/1gm:
2164-33-2
45 suppliers
$68.50/5g
Yield:2164-33-2 87%
Reaction Conditions:
with thionyl chloride in chloroform at 5; for 2.5 h;Reflux;Solvent;
Steps:
1.2 2) synthesis of 2 - chloromethyl - 1, 4 - benzene and dioxane:
The reaction flask is added 2 - hydroxy methyl 1, 4 - benzene and dioxane 25 g (150 mmol) and chloroform 50 ml, stirring and dissolving, lowering the temperature to 5 °C following, instillment chlorination sulfoxide 35.6 g (300 mmol), the exhaust gas generated by the sodium hydroxide solution for absorption, after dropping the temperature of the reflux reaction for 2.5 hours. After the reaction is preferably chloroform, in vacuum degree is 0.095 mpa collected under the condition of 110 - 125 °C fraction, shall be the oil of 2 - chloromethyl - 1, 4 - benzene and dioxane 24.1 g, yield 87%.
References:
CN105061392,2017,B Location in patent:Paragraph 0026; 0027; 0034; 0035
120-80-9
525 suppliers
$13.00/25g
2164-33-2
45 suppliers
$68.50/5g
