
2-Chloro-5-methylpyridine-3-carboxylic acid synthesis
- Product Name:2-Chloro-5-methylpyridine-3-carboxylic acid
- CAS Number:66909-30-6
- Molecular formula:C7H6ClNO2
- Molecular Weight:171.58

65169-43-9

66909-30-6
General procedure for the synthesis of 2-chloro-5-methylnicotinic acid from 2-chloro-5-methylnicotinic acid methyl ester: Intermediate 31 (2-chloro-5-methylnicotinic acid methyl ester, 0.38 g, 1.81 mmol) was dissolved in methanol (2 ml) and 2N sodium hydroxide solution (1.81 ml, 3.62 mmol) was added. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the mixture was concentrated to dryness and the residue was redissolved in ethyl acetate/water. The organic layer was separated, dried over magnesium sulfate and subsequently concentrated in vacuum to afford the target product 2-chloro-5-methylnicotinic acid as a white solid in 94% yield.LRMS: m/z 172 (M + 1)+; retention time: 3.25 min.1H NMR (200 MHz, DMSO-D6) δppm: 2.2 (s, 3H); 7.6 (d, J = 2.53 Hz , 1H); 8.0 (d, J = 2.53 Hz, 1H).

65169-43-9
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66909-30-6
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$8.00/250mg
Yield: 94%
Reaction Conditions:
with methanol;sodium hydroxide;water at 20; for 2 h;
Steps:
32
INTERMEDIATE 322-Chloro-5-methylnicotinic acid; Intermediate 31 (0.38g, 1.81mmol) was dissolved in MeOH (2ml) and 2N NaOH solution was added (1.81ml, 3.62mmol) and the mixture stirred at room temperature for 2 hours. The reaction mixture was concentrated to dryness and the residue redissolved in EtOAc/
References:
LABORATORIOS ALMIRALL, S.A. WO2008/77639, 2008, A1 Location in patent:Page/Page column 26-27

124-38-9
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66909-30-6
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$8.00/250mg

18368-64-4
456 suppliers
$10.00/1g

124-38-9
132 suppliers
$175.00/23402

66909-30-6
118 suppliers
$8.00/250mg

18368-64-4
456 suppliers
$10.00/1g

66909-30-6
118 suppliers
$8.00/250mg