2-CHLORO-3-CYANOQUINOLINE synthesis
- Product Name:2-CHLORO-3-CYANOQUINOLINE
- CAS Number:95104-21-5
- Molecular formula:C10H5ClN2
- Molecular Weight:188.61
73568-25-9
95104-21-5
General procedure for the synthesis of 2-chloro-3-cyanoquinoline from 2-chloro-3-quinolinecarboxaldehyde: 2-chloroquinoline-3-carboxaldehyde (0.01 mol) was suspended in 30% ammonia (30 mL) and stirred at room temperature for 5 min to form a turbid solution. Stirring was continued at 0 °C and ceric ammonium nitrate (0.01 mol) was slowly added. The reaction process was monitored by thin layer chromatography (TLC) and the reaction time was about 10-15 minutes. After completion of the reaction, the reaction mixture was extracted with a solvent mixture of chloroform-ethyl acetate (5:3 v/v). The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was recrystallized by ethanol to give pure 2-chloro-3-cyanoquinoline as light yellow crystals in 82% yield.
73568-25-9
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95104-21-5
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$39.00/100mg
Yield:95104-21-5 98%
Reaction Conditions:
with hydroxylamine hydrochloride;2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide;triethylamine in ethyl acetate;N,N-dimethyl-formamide at 100;
References:
Augustine, John Kallikat;Atta, Rajendra Nath;Ramappa, Balakrishna Kolathur;Boodappa, Chandrakantha [Synlett,2009,# 20,p. 3378 - 3382] Location in patent:experimental part
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95104-21-5
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95104-21-5
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95104-21-5
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$39.00/100mg