(2-Bromothien-3-yl)methanol synthesis
- Product Name:(2-Bromothien-3-yl)methanol
- CAS Number:70260-16-1
- Molecular formula:C5H5BrOS
- Molecular Weight:193.06
71637-34-8
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70260-16-1
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Yield:70260-16-1 91%
Reaction Conditions:
with NBS;glacial acetic acid at 20; for 0.75 h;
Steps:
8 2-BROMO-3-HYDROXYMETHYLTHIOPHENE (13)
To a solution of 3-hydroxymethylthiophene 12 (4.06 g, 35.6 mmol) in 18 mL of acetic acid was added N-bromosuccinimide (6.34 g, 35.6 mol) at room temperature and stirred for 45 minutes. The resulting mixture was quenched with 1 mL of water, poured into 250 mL ether and washed with 100 mL of water, 100 mL of 10% NAHC03 aq. respectively. The organic layer was dried over NA2S04 and concentrated. 6.25 G of crude product 13 (91 %) was obtained and used for the subsequent reaction without further purification.
References:
WO2004/65384,2004,A1 Location in patent:Page 36; 16/19
40032-76-6
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70260-16-1
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70260-16-1
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