2,5-Dimethoxyacetoacetanilide synthesis
- Product Name:2,5-Dimethoxyacetoacetanilide
- CAS Number:6375-27-5
- Molecular formula:C12H15NO4
- Molecular Weight:237.25
Yield: 93%
Reaction Conditions:
in tolueneDean-Stark;Reflux;
Steps:
7 Synthesis of compound 7-b
Compound 7-a (2,5-dimethoxyaniline, 10.0 g, 65.28 mmol) was dissolved in toluene (130 ml) and then ethyl acetoacetate (8.3 ml, 65.28 mmol) was added thereto. A Dean-Stark apparatus was installed, followed by refluxing overnight. Toluene was evaporated after terminating reaction and then a crude product was purified through column chromatography { Ethyl acetate (EA):hexane (HX)= 1: 1} and recrystallization.Yield: 93%
References:
KT&G LIFE SCIENCE CO., LTD;LEE, HWEE SUNG;LEE, MI JUNG;KIM, BO JUNG;NOH, TAE CHUL;LEE, SUNG HOON;LEE, GYU DAE;LEE, YU HEE;KWAK, TAE HWAN KR2015/80425, 2015, A Location in patent:Paragraph 0263-0267
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