2,4-Difluorophenylacetic acid synthesis
- Product Name:2,4-Difluorophenylacetic acid
- CAS Number:81228-09-3
- Molecular formula:C8H6F2O2
- Molecular Weight:172.13
81228-02-6
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81228-09-3
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Yield:81228-09-3 146 g
Reaction Conditions:
with ozone in chlorobenzene at 0; for 1.5 h;
Steps:
The former oil was added to 180 g of chlorobenzene (1.62 mol, 200 ml), stirred and dissolved, and the system was cooled to 0 ° C, and slowly passed into O3.During this process, solids gradually precipitated. The reaction was completed in about 1.5 hours.The system was added with 150 ml of water, adjusted to pH 11 with NaOH, and the organic layer was separated.The aqueous layer was back-extracted with 100 ml x 3 dichloromethane.After separating the organic layer, the aqueous layer was adjusted to pH 1 with concentrated hydrochloric acid.A large amount of crystals precipitated. Filter, wash the filter cake with ice water, dry,A white powder of 146 g of 2,4-difluorophenylacetic acid was obtained.The yield was 85% based on m-difluorobenzene.
References:
Zhejiang Shaxing Technology Co., Ltd.;Huang Xiaoting CN108752218, 2018, A Location in patent:Paragraph 0026
23915-07-3
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81228-09-3
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372-18-9
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81228-09-3
274 suppliers
$12.00/2 g