2,4-Difluorophenol synthesis
- Product Name:2,4-Difluorophenol
- CAS Number:367-27-1
- Molecular formula:C6H4F2O
- Molecular Weight:130.09
144025-03-6
397 suppliers
$6.00/1g
367-27-1
344 suppliers
$6.00/5g
Yield:367-27-1 92%
Reaction Conditions:
with dihydrogen peroxide in water at 20;chemoselective reaction;
Steps:
4 2.4. Ipso-hydroxylation of phenylboronic acid
General procedure: In a 50 mL round-bottomed flask, a mixture of arylboronic acid(1 mmol), H2O2 (30% aq, 0.2 mL), ZnO nanocatalyst (5 mol%; sampleZnO-1) and 2 mL of water were stirred at room temperature under aerobic condition. The progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was diluted with 20 mL of water and extracted with (3×20) mL of diethyl ether. The combined organic layer was washed with brine and dried over Na2SO4. The solvent was removed in a rotary evaporator under reduced pressure. The crude product was purified by column chromatography (hexane/ ethylacetate, 9:1) on silica (100-200mesh) to get the desired product. The products were identified by 1HNMR and 13C NMR.
References:
Phukan, Shreemoyee;Mahanta, Abhijit;Rashid, Md. Harunar [Applied Catalysis A: General,2018,vol. 562,p. 58 - 66]
348-57-2
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$5.00/5g
367-27-1
344 suppliers
$6.00/5g
108-95-2
764 suppliers
$14.00/25g
371-41-5
532 suppliers
$8.00/25g
367-12-4
435 suppliers
$5.00/10g
367-27-1
344 suppliers
$6.00/5g
108-95-2
764 suppliers
$14.00/25g
371-41-5
532 suppliers
$8.00/25g
367-12-4
435 suppliers
$5.00/10g
367-27-1
344 suppliers
$6.00/5g
28177-48-2
312 suppliers
$15.00/5 g