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ChemicalBook CAS DataBase List 2-(1H-IMIDAZOL-2-YL)-PYRAZINE
119165-68-3

2-(1H-IMIDAZOL-2-YL)-PYRAZINE synthesis

2synthesis methods
-

Yield:119165-68-3 57%

Reaction Conditions:

Stage #1: 2-pyrazine carbonitrilewith sodium methylate in methanol at 20; for 0.666667 h;
Stage #2: 2,2-dimethoxyethylaminewith acetic acid in methanol at 50; for 1 h;
Stage #3: with hydrogenchloride in methanol;water; for 5 h;Reflux;

References:

Aaker?y, Christer B.;Wijethunga, Tharanga K.;Benton, Joshua;Desper, John [Chemical Communications,2015,vol. 51,# 12,p. 2425 - 2428] Location in patent:supporting information