2-Methylbenzofuro[2,3-b]pyridin-8-yl trifluoromethanesulfonate synthesis
- Product Name:2-Methylbenzofuro[2,3-b]pyridin-8-yl trifluoromethanesulfonate
- CAS Number:1609373-98-9
- Molecular formula:C13H8F3NO4S
- Molecular Weight:331.27
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Yield:1609373-98-9 80%
Reaction Conditions:
with pyridine in dichloromethane at 0;
Steps:
Preparation of 2-methylbenzofuro[2,3-b]pyridin-8-yl trifluoromethanesulfonate
Into a suspension of 2-methylbenzofuro[2,3-b]pyridin-8-ol (6.7 g, 33.6 mmol) in dichloromethane (300 ml) wasadded dropwise a solution of trifluoromethanesulfonic anhydride (8.47 ml, 50.5 mmol) in dichloromethane (30 ml) at 0°C. After stirring overnight, the reaction was quenched with saturated sodium bicarbonate. The organic phase wasisolated, washed with brine and dried over sodium sulfate. Upon evaporation off the solvent, the crude product waspurified by column chromatography on silica gel with dichloromethane as eluent to obtain 8.95 g (80%) of desired productas a pale yellow solid.
References:
EP2730583,2014,A1 Location in patent:Paragraph 0155; 0156
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