2-Pyridinecarboxylic acid, 3-broMo-6-chloro-, Methyl ester synthesis
- Product Name:2-Pyridinecarboxylic acid, 3-broMo-6-chloro-, Methyl ester
- CAS Number:1214328-96-7
- Molecular formula:C7H5BrClNO2
- Molecular Weight:250.48
67-56-1
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1214328-96-7
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Yield:1214328-96-7 100%
Reaction Conditions:
with sulfuric acid for 28 h;Reflux;
Steps:
1
EXAMPLE 1 Synthesis of 3-bromo-6-chloro-pyridine-2-carboxylic acid methyl ester.3-Bromo-6-chloro-pyridine-2-carboxylic acid (50.00 g, 21 1.5 mmol) was dissolved in methanol (235 mL), and concentrated sulphuric acid (5.6 mL) was added. The resulting reaction mixture was heated to reflux for 28 h. The reaction mixture was cooled to room temperature, and the resulting precipitate was recrystallized from methanol to give 3-bromo- 6-chloro-pyridine-2-carboxylic acid methyl ester (54.38 g, quantitative) as a solid.Characterising data for the compound are as follows: 1H NMR (400 MHz, CDC13) δ ppm 7.94 (d, 1H), 7.34 (d, 1H) and 4.01 (s, 3H).
References:
SYNGENTA LIMITED;WHITTINGHAM, William Guy;HACHISU, Shuji;ASPINALL, Mary, Bernadette;HOTSON, Matthew, Brian WO2011/144891, 2011, A1 Location in patent:Page/Page column 56
929000-66-8
169 suppliers
$19.00/1g
74-88-4
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$15.00/10g
1214328-96-7
62 suppliers
$36.00/100mg
929000-66-8
169 suppliers
$19.00/1g
1214328-96-7
62 suppliers
$36.00/100mg