1-tosyl-1H-benzo[d]imidazole synthesis
- Product Name:1-tosyl-1H-benzo[d]imidazole
- CAS Number:15728-44-6
- Molecular formula:C14H12N2O2S
- Molecular Weight:272.32
Yield:15728-44-6 93%
Reaction Conditions:
with NBS in 1,4-dioxane at 25; for 12 h;Reagent/catalyst;Solvent;Temperature;
Steps:
8 Example 8
In the drying tube was added 59mg benzimidazoleAnd 178mg of methyl benzene sulfinateSodium, was added 89mg of NBS. Was then added 2mL of 1,4-dioxane to dissolve the solid, the reaction solution was stirred at 25 12 hours. After completion of the reaction, ethyl acetate and water extraction, the resulting organic phase was concentrated on a rotary evaporator, silica gel column (ethyl acetate and petroleum ether, the volume ratio of 1: 3) to give the product 126mg, yield 93% , the following reaction formula:
References:
CN105693621,2016,A Location in patent:Paragraph 0076; 0077; 0078; 0079; 0080; 0081
