1-(4-hydroxyphenyl)-2-methoxyethan-1-one synthesis
- Product Name:1-(4-hydroxyphenyl)-2-methoxyethan-1-one
- CAS Number:32136-81-5
- Molecular formula:C9H10O3
- Molecular Weight:166.17
2491-38-5
275 suppliers
$5.00/100mg
32136-81-5
58 suppliers
$110.00/250mg
Yield: 85%
Reaction Conditions:
with sodium hydroxide in methanol
Steps:
3 Preparation of alpha-methoxy-4-hydroxyacetophenone
EXAMPLE 3 Preparation of alpha-methoxy-4-hydroxyacetophenone 2 g of alpha-bromo-4-hydroxyacetophenone are dissolved in 11 g of methanol. 30 g of a saturated solution of sodium hydroxide in methanol (1 g NaOH/ 4.2 ml methanol) is added dropwise to the alpha-bromo-4-hydroxyacetophenone solution. After the addition is complete, the solution is added to 30 g of ice and acidified to pH 6. Alpha-methoxy-4-hydroxyacetophenone precipitates out and is filtered and dried to a greenish yellow product in about 85% yield; the product is determined by 1-H-NMR to be substantially pure.
References:
Hoechst Celanese Corporation US5107034, 1992, A
2491-38-5
275 suppliers
$5.00/100mg
124-41-4
726 suppliers
$12.00/25g
32136-81-5
58 suppliers
$110.00/250mg
2491-38-5
275 suppliers
$5.00/100mg
7440-44-0
349 suppliers
$12.00/25g
32136-81-5
58 suppliers
$110.00/250mg
67-56-1
782 suppliers
$7.29/5ml-f
99-93-4
914 suppliers
$5.00/25g
32136-81-5
58 suppliers
$110.00/250mg
6305-04-0
125 suppliers
$150.00/50 mg
124-41-4
726 suppliers
$12.00/25g
32136-81-5
58 suppliers
$110.00/250mg