天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 1-(3-Nitrophenyl)piperazine
54054-85-2

1-(3-Nitrophenyl)piperazine synthesis

6synthesis methods
-

Yield: 72%

Reaction Conditions:

with potassium carbonate in dimethyl sulfoxide at 100; for 24 h;

Steps:

2-1; 3.1
A mixture of piperazine (12 g, 138 mmol), 1-fluoro-3-nitrobenzene (4 ml, 34 mmol) and potassium carbonate (9.60 g, 69 mmol) in DMSO (40 mL) is heated at 100°C for 24 h. The reaction is quenched with H2O (60 mL) and extracted with Et2O (3 x 20 mL). The organic layer is washed with brine (20 mL) and dried over Na2SO4 and concentrated in vacuo. The residue is chromatographied on silica gel eluting with CH2Cl2/ MeOH (94 / 6) to yield the title compound (5.15 g, 72%) as an orange solid. This solid was dissolved in CH2Cl2 and Boc2O (6 g, 130 mmol) was added. The mixture was stirred overnight. The solvent was evaporated and the residual solid was crystallized in heptane (6.80 g, 93%, mp 86°C). 1H NMR (200 MHz, CDCl3) δ 1.49 (s, 9 H), 3.22-3.27 (m, 4 H), 3.58-3.63 (m, 4 H), 7.16-7.71 (m, 4 H).

References:

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) EP1683790, 2006, A1 Location in patent:Page/Page column 7; 12