1,1,1,3,3,3-Hexafluoro-2-propanol synthesis
- Product Name:1,1,1,3,3,3-Hexafluoro-2-propanol
- CAS Number:920-66-1
- Molecular formula:C3H2F6O
- Molecular Weight:168.04
26103-07-1
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920-66-1
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28523-86-6
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Yield:28523-86-6 93% ，920-66-1 1.05 %Chromat.
Reaction Conditions:
with hydrogenchloride;potassium fluoride;water;Aliquat HTA-1 at 100; for 3 h;Product distribution / selectivity;
Steps:
13
EXAMPLE 13; A mixture of (CF3)2CHOCH2C143.2 g (0.2 mole), potassium fluoride 12.76 g (0.22 mole), 10 cc of 1.0 N HCl (0.01 mole), and 1 g of Aliquat HTA-I was heated at 100 °C for S hours. Water was added to dissolve the precipitated salts, and the product was recovered by azeotropic distillation using a Dean Stark trap. The recovered product weighed 38.7 g and was analyzed by gas chromatography. The product was 80% (CF3)2CHOCH2F and 18.5% (CF3)2CHOCH2C1. There was 1.05% of (CF3)2CHOH. Conversion was 83% and yield was 93%.
References:
WO2006/55748,2006,A2 Location in patent:Page/Page column 12
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