2-氨基噻唑簡(jiǎn)介

2-Aminothiazole is a heterocyclic amine featuring an thiazole core. It can also be considered a cyclic isothiourea. It possesses an odor similar to pyridine and is soluble in water, alcohols and diethyl ether. It is commonly used as a starting point for the synthesis of many compounds including sulfur drugs, biocides, fungicides, dyes and chemical reaction accelerators. 2-Aminothiazole can be used as a thyroid inhibitor in the treatment of hyperthyroidism and has antibacterial activity. Alternatively, its acid tartrate salt can be used. Recent studies using prion-infected neuroblastoma cell lines have suggested that aminothiazole may be used as a therapeutic drug for prion diseases.

2-氨基噻唑物化性質(zhì)

外觀與性狀：淡棕色晶體或棕色粒狀的固體 沸點(diǎn)：117 °C (15.002 mmHg) 熔點(diǎn)：91-93 °C(lit.) 閃點(diǎn)：117°C/15mm 水溶解性：100 g/L (20 oC) 穩(wěn)定性：Stable under normal temperatures and pressures. 儲(chǔ)存條件：庫房通風(fēng)低溫干燥,與硝酸,硫酸分開存放

安全信息

RTECS號(hào)： XJ2100000 安全說明： S26-S36/37-S39 危險(xiǎn)類別碼： R22; R36/37 WGK Germany： 3 危險(xiǎn)品運(yùn)輸編碼： 2811 海關(guān)編碼： 2934999090 包裝等級(jí)： I; II; III 危險(xiǎn)品標(biāo)志： Xn

生產(chǎn)方法及用途

生產(chǎn)方法

由硫脲與氯乙醛(或乙醇和氯氣,或α,β二氯乙基乙醚)經(jīng)環(huán)合而得。在反應(yīng)器中加入熱水、硫脲和α,β-二氯乙基乙醚。在攪拌下回流2h。冷卻,經(jīng)滴液漏斗加入氫氧化鈉溶液,使溶液呈堿性,析出2-氨基噻唑晶體。然后加入乙醚使之溶解。分出醚層,用水洗滌后,以無水硫酸鈉干燥,蒸出乙醚得粗品。用乙醇重結(jié)晶,得黃色晶體。產(chǎn)率為80%,熔點(diǎn)90℃。

用途

2-氨基噻唑主要用于合成硝基磺胺噻唑（Nitrosulfathiazole）、磺胺噻唑（Sulfathiazole）、琥磺噻唑（Sulfasuxidinum）、馬來?；前粪邕颍–arbothiazol）、酞磺胺噻唑（Phthalylsulfathiazole）、克瀉磺（Oxyquinoline)，還用作染料中間體。