產(chǎn)品英文名稱：
Recombinant Human Retinoblastoma Associated Protein

英文簡(jiǎn)稱:
RB1

中文名稱:
重組人視黃酸受體應(yīng)答蛋白2

背景資料:
Retinoblastoma （RB） is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral. Spontaneous regression （’cure’） occurs in some cases. Retinoblastoma acts as a regulator of other genes and forms a complex with adenovirus e1a and with sv40 large t antigen. Retinoblastoma acts as a tumor suppressor and modulats functionally certain cellular proteins with which t and e1a compete for pocket binding. Retinoblastoma is potent inhibitor of e2f-mediated trans-activation， recruits and targets histone methyltransferase suv39h1 leading to epigenetic transcriptional repression， inhibits the intrinsic kinase activity of taf1.

產(chǎn)品描述:
Retinoblastoma Human Recombinant fused with 6X His tag produced in E.Coli is a single， non-glycosylated， polypeptide chain containing 146 amino acids and having a molecular mass of 16.5 kDa.The Retinoblastoma is purified by proprietary chromatographic techniques.
來源宿主:
大腸桿菌中重組表達(dá)

序列:
MASFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQKMNDSMDTSNKEEKHHHHHH.

溶解建議:
Sterile Filtered White lyophilized （freeze-dried） powder. The RB1 （1 mg/ml） was lyophilized after extensive dialyses against 1xPBS pH-7.4. It is recommended to reconstitute the lyophilized Retinoblastoma in sterile 18MΩ-cm H2O not less than 100 ug/ml， which can then be further diluted to other aqueous solutions.

保存建議：
Lyophilized Retinoblastoma although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution Retinoblastoma should be stored at 4℃ between 2-7 days and for future use below -18℃.For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.Please prevent freeze-thaw cycles.
其他簡(jiǎn)介：

? ProSpec是一家全球著名細(xì)胞因子蛋白及相關(guān)抗體生產(chǎn)和研發(fā)品牌。ProSpec的生產(chǎn)和研發(fā)工廠位于以色列，專注于蛋白（重組及合成）生產(chǎn)研發(fā)，其獨(dú)有的細(xì)菌和哺乳動(dòng)物表達(dá)和蛋白折疊技術(shù)使其能在17年內(nèi)成長(zhǎng)為國(guó)際一流的科研級(jí)蛋白供應(yīng)商。目前ProSpec可以提供細(xì)胞因子，生長(zhǎng)因子，激素，信號(hào)蛋白，病毒抗原等近800種重組蛋白和100多種抗體，是世界上提供蛋白品種最多的公司之一，領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級(jí)蛋白，價(jià)格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白?？紤]到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護(hù)劑或鹽，這就對(duì)工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。
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