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抑制劑描述：

產(chǎn)品名稱：Flutamide

產(chǎn)品別名：氟他胺

英文別名：SCH 13521

靶點：Androgen Receptor

CAS：13311-84-7

純度：＞98%

外觀：淡黃色結晶性粉末

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor.

溶解性：DMSO : 51 mg/mL (184.6 mM)
Ethanol : 51 mg/mL (184.6 mM)

體外研究：

Flutamide (Eulexin) is an antiandrogen drug. Flutamide-OH, the active metabolite of flutamide, directly binds at rat anterior pituitary androgen receptor with Ki values of 55 nM. Flutamide does not affect the proliferation of an androgen-sensitive clone of the mouse mammary carcinoma Shionogi SC-l 15 cells in culture, shows only antiandrogenic effect, but not androgenic effect. Flutamide provides treatment for prostate cancer when used along with leuprolide.

體內(nèi)研究：Flutamide causes a markedly reduction in rat ventral prostate weight from 319 mg to 245 mg. A combination of flutamide and LHRH agonist induces an additive effect with a decrease in prostate weight to 101 mg, and an marked drop in prostatic ODC activity.

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