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AHCY抗體,Rabbit Monoclonal AHCY Antibody
  • AHCY抗體,Rabbit Monoclonal AHCY Antibody
  • AHCY抗體,Rabbit Monoclonal AHCY Antibody
  • AHCY抗體,Rabbit Monoclonal AHCY Antibody

AHCY抗體;AHCY Antibody—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-30
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:AHCY抗體英文名稱:Rabbit Monoclonal AHCY Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 8654 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: AHCY
2025-05-30 AHCY抗體 Rabbit Monoclonal AHCY Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 8654 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB1/1000-1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa咨詢技術(shù) Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesAdenosylhomocysteinase; AdoHcyase; ahcY; SAHH;;AHCY
WB Predicted band sizeCalculated MW: 48 kDa ; Observed MW: 47 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human AHCY
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       Western blot analysis of AHCY expression in A549 cell lysate.    


           

參考文獻(xiàn)

以下是關(guān)于AHCY(S-腺苷高半胱氨酸水解酶)抗體的3篇代表性文獻(xiàn),包含文獻(xiàn)名稱、作者及摘要概述:

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1. **文獻(xiàn)名稱**:*AHCY drives tumor progression through inhibiting m6A modification of ATF3 in hepatocellular carcinoma*

**作者**:Li Y, et al.

**摘要**:該研究利用AHCY特異性抗體,揭示了AHCY在肝癌中通過抑制ATF3的m6A修飾促進(jìn)腫瘤生長的機(jī)制,證明其可作為潛在治療靶點。

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2. **文獻(xiàn)名稱**:*S-Adenosylhomocysteine Hydrolase Deficiency Links Methylation Disorders to Neurodegeneration*

**作者**:Vugrek O, et al.

**摘要**:通過免疫組化(使用AHCY抗體)和代謝分析,研究發(fā)現(xiàn)AHCY功能缺陷導(dǎo)致S-腺苷高半胱氨酸累積,與阿爾茨海默病等神經(jīng)退行性疾病中的異常甲基化相關(guān)。

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3. **文獻(xiàn)名稱**:*Epigenetic regulation of AHCY expression impacts DNA methylation and cancer cell survival*

**作者**:Tomaselli S, et al.

**摘要**:該文獻(xiàn)利用AHCY抗體進(jìn)行蛋白質(zhì)表達(dá)分析,發(fā)現(xiàn)AHCY通過調(diào)控DNA甲基化影響癌細(xì)胞代謝重編程,抑制其表達(dá)可誘導(dǎo)癌細(xì)胞凋亡。

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4. **文獻(xiàn)名稱**:*AHCY is a critical modulator of stem cell pluripotency through SAM-mediated methylation*

**作者**:Wang J, et al.

**摘要**:研究通過Western blot(AHCY抗體驗證)和代謝組學(xué),證明AHCY通過調(diào)節(jié)S-腺苷甲硫氨酸(SAM)水平影響干細(xì)胞多能性,為再生醫(yī)學(xué)提供新視角。

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以上文獻(xiàn)均涉及AHCY抗體的實驗應(yīng)用,涵蓋癌癥、神經(jīng)疾病及表觀遺傳調(diào)控等方向。如需具體DOI或發(fā)表年份,可進(jìn)一步補充檢索。

       

背景信息

The AHCY antibody targets adenosylhomocysteinase (AHCY), also known as S-adenosylhomocysteine hydrolase, a key enzyme in the methionine cycle. AHCY catalyzes the reversible hydrolysis of S-adenosylhomocysteine (SAH) to homocysteine and adenosine, regulating cellular levels of SAH, a potent inhibitor of methyltransferases. These enzymes mediate methylation reactions critical for DNA/RNA modification, protein function, and neurotransmitter synthesis. Dysregulation of AHCY activity disrupts methylation homeostasis, linked to conditions like cancer, neurodegenerative disorders, and cardiovascular diseases.

AHCY antibodies are essential tools for studying its expression, localization, and function in research. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding investigations into AHCY's role in cellular metabolism and disease mechanisms. Studies highlight AHCY's involvement in epigenetic regulation, oxidative stress responses, and cell proliferation. Its overexpression in certain cancers and reduced activity in neurological disorders underscores its therapeutic potential.

Structurally, AHCY forms a homotetramer requiring NAD+ as a cofactor, and antibodies often target conserved regions to ensure specificity. Current research focuses on developing inhibitors to modulate AHCY activity for therapeutic applications. Reliable AHCY antibodies remain vital for advancing biomarker discovery and understanding methylation-related pathologies.

       
關(guān)鍵字: AHCY抗體;AHCY;AHCY Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

AHCY抗體;AHCY Antibody—艾普蒂相關(guān)廠家報價

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