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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P11745(ESRRB Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11745(ESRRB Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

ESRRB (Estrogen-Related Receptor Beta) is a nuclear receptor transcription factor belonging to the NR3B subfamily. It plays critical roles in embryonic development, placental formation, and the maintenance of pluripotency in embryonic stem cells (ESCs). ESRRB regulates target genes by binding to specific DNA response elements, often in coordination with co-activators like PGC-1α. Structurally, it contains a DNA-binding domain (DBD) and a ligand-binding domain (LBD), though its endogenous ligand remains unidentified. Notably, ESRRB is a core component of the regulatory network sustaining ESC self-renewal, interacting with key pluripotency factors such as OCT4. NANOG, and SOX2. It also contributes to cellular reprogramming, where its overexpression enhances induced pluripotent stem cell (iPSC) generation.

ESRRB antibodies are widely used to study its expression, localization, and function in developmental biology, regenerative medicine, and cancer research. These antibodies enable techniques like Western blotting, immunofluorescence, chromatin immunoprecipitation (ChIP), and flow cytometry. Dysregulation of ESRRB has been implicated in cancers (e.g., prostate, breast) and placental disorders, making its detection crucial for understanding disease mechanisms. Validation of ESRRB antibodies includes testing in knockout cell lines and verifying specificity for its ~50 kDa protein band. Researchers rely on these tools to explore ESRRB's role in gene regulation, stem cell dynamics, and potential therapeutic applications.