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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human cerebrum tissue, Human cerebella tissue, Mouse brain tissue lysates, Primary antibody: P10393(ENKD1 Antibody) at dilution 1/1150, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10393(ENKD1 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

The ENKD1 (Enkurin Domain Containing 1) antibody is a tool used to detect and study the ENKD1 protein, which is encoded by the ENKD1 gene. Enkurin, a conserved domain in ENKD1. is implicated in calcium signaling pathways, particularly through interactions with transient receptor potential (TRP) ion channels. ENKD1 is predominantly expressed in testicular tissues and plays a role in sperm development and function, suggesting its importance in male fertility. It has also been linked to cilia function and cellular mechanotransduction processes.

The ENKD1 antibody is widely utilized in research to investigate protein localization, expression levels, and molecular interactions via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Its applications extend to studying reproductive biology, ciliopathies, and conditions involving calcium signaling dysregulation. Commercial ENKD1 antibodies are typically raised in rabbits or mice, validated for specificity using knockout controls or siRNA silencing. Recent studies highlight ENKD1's potential role in cancer progression, particularly in tumors reliant on calcium-dependent signaling, though its mechanistic contributions remain under exploration. Researchers rely on this antibody to unravel ENKD1's physiological and pathological roles, bridging gaps in understanding cellular signaling and developmental disorders.