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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HL-60 cell lysate, Primary antibody: P10272(HYI Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P10272(HYI Antibody) at dilution 1/65. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P10272(HYI Antibody) at dilution 1/65. (Original magnification: ×200)    

  
  

HYI antibody is a research tool designed to target hydroxypyruvate isomerase (HYI), an enzyme encoded by the *HYI* gene in humans. HYI plays a critical role in the pentose phosphate pathway, particularly in catalyzing the isomerization of hydroxypyruvate to tartronate semialdehyde, a step essential for carbohydrate metabolism and cellular redox balance. Dysregulation of HYI has been implicated in metabolic disorders and rare genetic conditions like primary hyperoxaluria type 3. where mutations in *HYI* disrupt glyoxylate metabolism, leading to excessive oxalate production and kidney damage.

Developed primarily in model organisms like rabbits or mice, HYI antibodies are polyclonal or monoclonal reagents validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence. These antibodies enable researchers to study HYI expression patterns, localization, and abundance across tissues, providing insights into its physiological and pathological roles. Recent studies also explore HYI's potential links to cancer metabolism, where altered enzyme activity may influence tumor progression or therapeutic resistance. As a reagent, HYI antibody supports both basic biochemical research and clinical investigations, aiding in biomarker discovery and mechanistic studies of metabolic diseases.