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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P10003(RNASE4 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The RNASE4 antibody is a research tool designed to detect and study Ribonuclease 4 (RNASE4), a member of the RNase A superfamily. RNASE4. encoded by the *RNASE4* gene in humans, is a secreted enzyme with ribonucleolytic activity, primarily involved in RNA metabolism and degradation. It shares structural homology with angiogenin (RNASE5), including conserved catalytic residues and disulfide bonds, but exhibits distinct substrate specificity and biological roles. RNASE4 is expressed in various tissues, including the liver, kidney, and vascular endothelium, and has been implicated in angiogenesis, neuroprotection, and host defense mechanisms.

Antibodies targeting RNASE4 are typically monoclonal or polyclonal, developed using immunogens derived from specific epitopes of the human protein. These antibodies are validated for applications such as Western blotting, immunohistochemistry, ELISA, and immunofluorescence to assess RNASE4 expression levels, localization, and regulation in physiological or pathological contexts. Research highlights RNASE4's dual roles in health and disease, including its protective effects in neurodegenerative conditions like amyotrophic lateral sclerosis (ALS) and potential contributions to cancer progression through vascular remodeling. Specificity validation is critical due to sequence similarities within the RNase A family. RNASE4 antibodies thus serve as essential tools for exploring its enzymatic functions, therapeutic potential, and biomarker utility in diverse biomedical studies.