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LPXN抗體,Rabbit Polyclonal LPXN Antibody
  • LPXN抗體,Rabbit Polyclonal LPXN Antibody
  • LPXN抗體,Rabbit Polyclonal LPXN Antibody
  • LPXN抗體,Rabbit Polyclonal LPXN Antibody

LPXN抗體—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-20
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:LPXN抗體英文名稱:Rabbit Polyclonal LPXN Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 5128 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): LPXN
2025-05-20 LPXN抗體 Rabbit Polyclonal LPXN Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 5128 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesLDPL
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human LPXN
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09902(LPXN Antibody) at dilution 1/60. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09902(LPXN Antibody) at dilution 1/60. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是假設(shè)性參考文獻(xiàn)示例,基于LPXN(Leupaxin)相關(guān)研究的常見方向整理而成:

1. **標(biāo)題**:*Leupaxin regulates cell migration and invasion in prostate cancer via FAK signaling*

**作者**:Brown, A. et al. (2016)

**摘要**:研究通過LPXN抗體阻斷實(shí)驗(yàn),發(fā)現(xiàn)LPXN通過激活黏著斑激酶(FAK)信號(hào)通路,促進(jìn)前列腺癌細(xì)胞骨架重組和侵襲轉(zhuǎn)移,提示其作為癌癥治療潛在靶點(diǎn)。

2. **標(biāo)題**:*Autoantibodies against LPXN in rheumatoid arthritis: Clinical relevance and pathogenic mechanisms*

**作者**:Zhang, L. et al. (2018)

**摘要**:檢測(cè)類風(fēng)濕性關(guān)節(jié)炎患者血清中LPXN抗體的存在,發(fā)現(xiàn)其與疾病活動(dòng)度相關(guān),并通過激活NF-κB通路加劇炎癥反應(yīng),提示其作為疾病生物標(biāo)志物的潛力。

3. **標(biāo)題**:*Leupaxin modulates immune synapse formation in T lymphocytes through integrin signaling*

**作者**:Smith, J. & Chen, R. (2020)

**摘要**:利用LPXN抗體及基因敲除技術(shù),揭示LPXN在T細(xì)胞免疫突觸形成中的關(guān)鍵作用,通過整合素-ILK通路調(diào)控細(xì)胞間信號(hào)傳遞,影響免疫應(yīng)答效率。

4. **標(biāo)題**:*Structural insights into Leupaxin’s interaction with cytoskeletal proteins*

**作者**:Lee, S. et al. (2017)

**摘要**:通過X射線晶體學(xué)和抗體表位定位,解析LPXN蛋白結(jié)構(gòu)與paxillin/vinculin的結(jié)合域,闡明其在細(xì)胞黏附復(fù)合物組裝中的分子機(jī)制。

**注**:以上為模擬示例,實(shí)際文獻(xiàn)需通過數(shù)據(jù)庫(如PubMed)檢索確認(rèn)。建議使用關(guān)鍵詞“Leupaxin antibody”或“LPXN function”查詢最新研究。

       

背景信息

Leupaxin (LPXN) is a cytosolic adaptor protein primarily expressed in hematopoietic cells, including macrophages, osteoclasts, and platelets. It belongs to the paxillin family of proteins, which mediate signal transduction by coordinating protein interactions at focal adhesions and cytoskeletal sites. LPXN contains four leucine-rich LD motifs and four LIM domains, enabling interactions with structural and signaling molecules such as FAK, Pyk2. and integrins. These interactions facilitate its role in regulating cell adhesion, migration, and survival through integrin-mediated signaling pathways.

Initially identified for its homology to paxillin, LPXN exhibits tissue-specific expression patterns, with prominent roles in immune and bone-resorbing cells. Studies highlight its involvement in osteoclast differentiation, platelet activation, and immune cell recruitment. Dysregulation of LPXN has been linked to pathological conditions, including cancer metastasis (e.g., prostate and breast cancers), autoimmune diseases, and thrombosis. For example, elevated LPXN expression in leukemia cells correlates with chemoresistance, while its suppression in osteoclasts impairs bone remodeling.

LPXN antibodies are critical tools for detecting protein expression, localization, and interaction partners in both research and diagnostics. They help elucidate LPXN’s mechanistic contributions to cellular processes and disease progression, offering potential therapeutic targets. Commercial LPXN antibodies are typically validated for applications like Western blotting, immunohistochemistry, and immunoprecipitation. Ongoing research focuses on its role in tumor microenvironment modulation and hematopoietic disorders, reinforcing its relevance in translational medicine.

       
關(guān)鍵字: LPXN抗體;LPXN;LPXN Antibody;

公司簡(jiǎn)介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

LPXN抗體—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1600.00
VIP10年
北京索萊寶科技有限公司
2025-08-06
¥2520
VIP6年
上海澤葉生物科技有限公司
2025-08-06
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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