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DTX2抗體,Rabbit Polyclonal DTX2 Antibody
  • DTX2抗體,Rabbit Polyclonal DTX2 Antibody
  • DTX2抗體,Rabbit Polyclonal DTX2 Antibody
  • DTX2抗體,Rabbit Polyclonal DTX2 Antibody

DTX2抗體;DTX2 Antibody—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-25
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:DTX2抗體英文名稱:Rabbit Polyclonal DTX2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3442 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): DTX2
2025-05-25 DTX2抗體 Rabbit Polyclonal DTX2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3442 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200-1/400 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesRNF58
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human DTX2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07250(DTX2 Antibody) at dilution 1/300. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于DTX2抗體的示例參考文獻(xiàn)(內(nèi)容為模擬示例,僅供參考):

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1. **文獻(xiàn)名稱**: "DTX2 regulates Notch signaling through ubiquitination of JAGGED1 in triple-negative breast cancer"

**作者**: Chen L, Wang Y, et al.

**摘要**: 本研究利用DTX2特異性抗體,通過免疫共沉淀和Western blot分析,發(fā)現(xiàn)DTX2作為E3泛素連接酶介導(dǎo)JAGGED1蛋白的降解,抑制Notch信號通路,從而抑制乳腺癌細(xì)胞侵襲。

2. **文獻(xiàn)名稱**: "Development of a high-affinity monoclonal antibody for DTX2 and its application in colorectal cancer prognosis"

**作者**: Suzuki H, Nakamura K, et al.

**摘要**: 報道了一種新型抗DTX2單克隆抗體的開發(fā),該抗體通過免疫組化驗(yàn)證,可用于結(jié)直腸癌組織樣本中DTX2蛋白的定量檢測,提示DTX2高表達(dá)與患者不良預(yù)后相關(guān)。

3. **文獻(xiàn)名稱**: "DTX2 promotes genomic instability by inhibiting p53 ubiquitination in ovarian cancer"

**作者**: Gupta R, Patel S, et al.

**摘要**: 研究通過RNA干擾和DTX2抗體功能實(shí)驗(yàn),證明DTX2通過競爭性結(jié)合MDM2抑制p53泛素化,導(dǎo)致p53蛋白積累并引發(fā)卵巢癌細(xì)胞化療耐藥。

4. **文獻(xiàn)名稱**: "Structural characterization of DTX2 and its interaction with the ESCRT complex"

**作者**: Martinez-Banaclocha M, et al.

**摘要**: 利用抗DTX2抗體進(jìn)行免疫熒光和質(zhì)譜分析,揭示了DTX2的C端結(jié)構(gòu)域與ESCRT-III復(fù)合物的相互作用,為研究其在細(xì)胞膜修復(fù)中的作用提供新機(jī)制。

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**注意**:以上文獻(xiàn)為示例,實(shí)際引用時請查詢真實(shí)數(shù)據(jù)庫(如PubMed、Web of Science)獲取準(zhǔn)確信息。

       

背景信息

The DTX2 antibody targets the Deltex homolog 2 (DTX2) protein, a member of the Deltex family of E3 ubiquitin ligases involved in regulating cellular processes such as Notch signaling, protein degradation, and immune responses. Initially identified as a homolog of Drosophila Deltex, DTX2 plays a role in modulating Notch pathway activity by promoting ubiquitination and degradation of Notch receptors or associated proteins, though its exact mechanisms remain under investigation. Beyond Notch signaling, DTX2 has been implicated in DNA damage repair, apoptosis, and T-cell activation, highlighting its functional diversity.

Antibodies against DTX2 are critical tools for studying its expression patterns, subcellular localization, and interactions in various tissues and disease models. Research has explored DTX2's potential roles in cancer, where dysregulation of ubiquitination pathways often contributes to tumor progression. For instance, DTX2 may act as a tumor suppressor or oncogene depending on context, making it a subject of interest in biomarker and therapeutic discovery. Commercial DTX2 antibodies are typically validated for applications like Western blotting, immunohistochemistry, and co-immunoprecipitation. However, variability in antibody specificity and cross-reactivity with other Deltex family members (e.g., DTX1. DTX3) necessitates careful validation in experimental settings. Ongoing studies aim to clarify DTX2's precise biological functions and its relevance to human diseases.

       
關(guān)鍵字: DTX2抗體;DTX2;DTX2 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (1年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:1年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

DTX2抗體;DTX2 Antibody—艾普蒂相關(guān)廠家報價

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