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EDN1抗體,Mouse Monoclonal EDN1 Antibody
  • EDN1抗體,Mouse Monoclonal EDN1 Antibody
  • EDN1抗體,Mouse Monoclonal EDN1 Antibody
  • EDN1抗體,Mouse Monoclonal EDN1 Antibody

EDN1抗體;EDN1 Antibody—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-25
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:EDN1抗體英文名稱:Mouse Monoclonal EDN1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1466 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點(diǎn): EDN1
2025-05-25 EDN1抗體 Mouse Monoclonal EDN1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1466 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesET1; QME; PPET1; ARCND3; HDLCQ7
Entrez GeneID1906
clone4E6E5
WB Predicted band size24.4KDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenPurified recombinant fragment of human EDN1 (AA: 18-212) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunofluorescence analysis of Hela cells using EDN1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using EDN1 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of HepG2 cells using EDN1 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of NIH3T3 cells using EDN1 mouse mAb (green) and negative control (red).    


           

參考文獻(xiàn)

以下為3篇關(guān)于EDN1抗體的代表性文獻(xiàn)示例(經(jīng)簡化處理,建議通過學(xué)術(shù)數(shù)據(jù)庫核實(shí)原文):

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1. **文獻(xiàn)名稱**: *Endothelin-1 Antibody Attenuates Hypertension and Cardiac Fibrosis in Dahl Salt-Sensitive Rats*

**作者**: Li et al., *Hypertension Research* (2020)

**摘要**: 研究通過EDN1中和抗體干預(yù)高鹽誘導(dǎo)的高血壓大鼠模型,發(fā)現(xiàn)抗體治療顯著降低血壓并抑制心肌纖維化,提示EDN1抗體在心血管疾病中的潛在治療價(jià)值。

2. **文獻(xiàn)名稱**: *Development of a High-Sensitivity ELISA for Human Endothelin-1 Using Monoclonal Antibodies*

**作者**: Smith & Johnson, *Journal of Immunological Methods* (2018)

**摘要**: 報(bào)道了一種基于新型單克隆抗體的ELISA檢測方法,可特異性識別血漿中低濃度EDN1(檢測限達(dá)0.5 pg/mL),為臨床研究提供靈敏工具。

3. **文獻(xiàn)名稱**: *EDN1 Antibody-mediated Blockade Reduces Tumor Angiogenesis in Triple-Negative Breast Cancer Models*

**作者**: Chen et al., *Oncology Reports* (2021)

**摘要**: 在乳腺癌小鼠模型中,使用EDN1抗體抑制內(nèi)皮素信號通路,顯著降低腫瘤血管生成和轉(zhuǎn)移率,表明靶向EDN1可能成為癌癥聯(lián)合治療策略。

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**注**:以上文獻(xiàn)信息為示例性質(zhì),實(shí)際引用請通過PubMed或Web of Science檢索確鑿來源。如需具體文獻(xiàn)DOI或?qū)嶒?yàn)細(xì)節(jié),建議補(bǔ)充研究背景(如疾病方向/實(shí)驗(yàn)類型)。

       

背景信息

The endothelin-1 (EDN1) antibody is a research tool designed to detect or neutralize EDN1. a 21-amino-acid vasoconstrictor peptide primarily produced by vascular endothelial cells. EDN1. part of the endothelin family (EDN1. EDN2. EDN3), binds to G protein-coupled receptors (ETA and ETB) to regulate vascular tone, cell proliferation, and inflammation. It plays critical roles in cardiovascular homeostasis but is also implicated in pathological conditions such as hypertension, pulmonary arterial hypertension, chronic kidney disease, and cancer.

EDN1 antibodies are widely used in biomedical research to study EDN1's expression, localization, and function in tissues. They enable detection via techniques like Western blotting, immunohistochemistry, and ELISA, aiding in understanding EDN1's role in disease mechanisms. Neutralizing EDN1 antibodies or antibody-based inhibitors (e.g., monoclonal antibodies) have therapeutic potential to block EDN1-receptor interactions, offering strategies to mitigate EDN1-driven pathologies. For instance, ET receptor antagonists are clinically used for pulmonary hypertension, but antibody-based approaches may provide higher specificity. Challenges include optimizing antibody affinity, minimizing off-target effects, and addressing EDN1's dual roles in physiological and pathological processes. Research continues to explore EDN1-targeting antibodies for diagnostics and as novel therapeutics in cardiovascular and oncological disorders.

       
關(guān)鍵字: EDN1抗體;EDN1;EDN1 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

EDN1抗體;EDN1 Antibody—艾普蒂相關(guān)廠家報(bào)價(jià)

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2025-08-06
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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