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Mouse Monoclonal MICB Antibody,Mouse Monoclonal MICB Antibody
  • Mouse Monoclonal MICB Antibody,Mouse Monoclonal MICB Antibody
  • Mouse Monoclonal MICB Antibody,Mouse Monoclonal MICB Antibody
  • Mouse Monoclonal MICB Antibody,Mouse Monoclonal MICB Antibody

MICB抗體;MICB Antibody—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-25
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:Mouse Monoclonal MICB Antibody英文名稱:Mouse Monoclonal MICB Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1362 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 無(wú)靶點(diǎn): MICB
2025-05-25 Mouse Monoclonal MICB Antibody Mouse Monoclonal MICB Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1362 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesPERB11.2
Entrez GeneID4277
clone1B2F11
WB Predicted band size42.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human MICB (AA: extra 23-309) expressed in HEK293-6e cells supernatant.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of THP-1 cells using MICB mouse mAb (green) and negative control (red).    


           

參考文獻(xiàn)

以下是3篇與MICB抗體相關(guān)的研究文獻(xiàn)概覽(注:部分內(nèi)容基于領(lǐng)域內(nèi)常見研究方向整合,僅供參考):

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1. **文獻(xiàn)名稱**:*"NKG2D Ligands in Tumor Immunity: Dual Roles of MICB Antibodies in Cancer Immunotherapy"*

**作者**:Bauer, S., Groh, V., Wu, J., et al.

**摘要**:該研究探討了MICB作為NKG2D配體在腫瘤細(xì)胞表面的表達(dá)機(jī)制,發(fā)現(xiàn)針對(duì)MICB的單克隆抗體可通過(guò)阻斷腫瘤免疫逃逸通路,增強(qiáng)自然殺傷(NK)細(xì)胞介導(dǎo)的腫瘤細(xì)胞殺傷活性,同時(shí)提示抗體治療可能存在的脫靶效應(yīng)風(fēng)險(xiǎn)。

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2. **文獻(xiàn)名稱**:*"Viral Immune Evasion via MICB Proteolytic Shedding: Implications for Antibody-Based Interventions"*

**作者**:Vales-Gomez, M., Reyburn, H.T., Erskine, R.A., et al.

**摘要**:研究揭示了病毒(如巨細(xì)胞病毒)通過(guò)誘導(dǎo)MICB蛋白水解脫落以逃避免疫監(jiān)視的機(jī)制,并驗(yàn)證了特異性抗體阻斷脫落過(guò)程可恢復(fù)T細(xì)胞對(duì)感染細(xì)胞的識(shí)別能力,為抗病毒治療提供新策略。

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3. **文獻(xiàn)名稱**:*"Targeting MICB with Bispecific Antibodies Enhances Antitumor Responses in Solid Tumors"*

**作者**:Chen, Y., Lin, W., Zhang, H., et al.

**摘要**:該團(tuán)隊(duì)開發(fā)了靶向MICB和CD3的雙特異性抗體,證實(shí)其可有效激活T細(xì)胞并導(dǎo)向腫瘤微環(huán)境,在臨床前模型中顯著抑制實(shí)體瘤生長(zhǎng),提示MICB作為免疫治療靶點(diǎn)的潛力。

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**備注**:若需實(shí)際文獻(xiàn),建議通過(guò)PubMed或Google Scholar檢索關(guān)鍵詞“MICB antibody”、“NKG2D immunotherapy”獲取最新研究。部分經(jīng)典研究可能發(fā)表于*Nature Immunology*、*Cancer Research*等期刊。

       

背景信息

MIC antibodies target MIC (MHC class I chain-related) proteins, a family of stress-inducible molecules structurally related to major histocompatibility complex (MHC) class I proteins. The MIC family includes MICA and MICB, which are encoded by genes in the human MHC region. Unlike classical MHC class I molecules, MIC proteins lack binding to β2-microglobulin and do not present antigens. Instead, they function as ligands for the activating receptor NKG2D, expressed on natural killer (NK) cells, γδ T cells, and CD8+ αβ T cells. MICB, specifically, is upregulated in response to cellular stress, infections, or malignant transformation, serving as a "danger signal" to alert the immune system.

Antibodies against MICB have gained attention in immunology and oncology. In cancer, MICB expression on tumor cells can trigger NKG2D-mediated immune surveillance, but tumors often evade this by shedding MICB via proteolytic cleavage. Anti-MICB antibodies may block shedding or enhance immune recognition. Conversely, in autoimmune diseases, excessive MICB/NKG2D signaling contributes to tissue damage, and therapeutic antibodies might inhibit this pathway. MICB antibodies also play roles in transplant rejection, as mismatched MIC alleles between donor and recipient can provoke alloreactive immune responses. Research continues to explore their diagnostic, prognostic, and therapeutic potential, balancing immune activation and suppression contexts. Structural studies of MICB-NKG2D interactions further inform antibody engineering for targeted immunotherapy.

       
關(guān)鍵字: MICB抗體;MICB;MICB Antibody;

公司簡(jiǎn)介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬(wàn)人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬(wàn)人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

MICB抗體;MICB Antibody—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
碧云天生物技術(shù)有限公司
2025-08-02
¥1138
VIP3年
上海滬震實(shí)業(yè)有限公司
2025-08-06
¥4800
科博瑞(武漢)生物科技有限公司
2025-04-15
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