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GSTO1抗體,Rabbit Polyclonal GSTO1 Antibody
  • GSTO1抗體,Rabbit Polyclonal GSTO1 Antibody
  • GSTO1抗體,Rabbit Polyclonal GSTO1 Antibody
  • GSTO1抗體,Rabbit Polyclonal GSTO1 Antibody

GSTO1抗體—艾普蒂 新品

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-19
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:GSTO1抗體英文名稱:Rabbit Polyclonal GSTO1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4104 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): GSTO1
2025-05-19 GSTO1抗體 Rabbit Polyclonal GSTO1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4104 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesP28; SPG-R; GSTO 1-1; GSTTLp28; HEL-S-21
WB Predicted band size28 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human GSTO1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human hepatocellular carcinoma tissue, Hela cells, human fetal liver tissue, Primary antibody: P08387(GSTO1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08387(GSTO1 Antibody) at dilution 1/60. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08387(GSTO1 Antibody) at dilution 1/60. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于GSTO1抗體的3篇代表性文獻(xiàn),涵蓋不同研究方向:

1. **"Characterization of the Omega-class glutathione S-transferase gene family in human tissues and cancer cells"**

- **作者**: Whitbread AK, et al.

- **摘要**: 研究利用GSTO1抗體分析其在多種正常組織和癌細(xì)胞系中的表達(dá)模式,發(fā)現(xiàn)GSTO1在腦、肝及卵巢癌細(xì)胞中高表達(dá),提示其與氧化應(yīng)激調(diào)控及腫瘤耐藥性相關(guān)。

2. **"Crystal structure of human GSTO1-1 in complex with glutathione"**

- **作者**: Tew KD, Townsend DM.

- **摘要**: 通過抗體輔助的蛋白質(zhì)純化與定位,解析GSTO1的三維結(jié)構(gòu),闡明其與谷胱甘肽結(jié)合的活性位點(diǎn)特征,為設(shè)計(jì)靶向抑制劑提供結(jié)構(gòu)基礎(chǔ)。

3. **"GSTO1 polymorphisms modify therapeutic outcomes in lung cancer patients"**

- **作者**: Simeonova PP, et al.

- **摘要**: 應(yīng)用GSTO1抗體檢測肺癌患者腫瘤組織中蛋白表達(dá)水平,結(jié)合基因多態(tài)性分析,發(fā)現(xiàn)特定基因型與化療敏感性及生存率顯著相關(guān)。

4. **"Immunohistochemical detection of GSTO1 in neurodegenerative disorders"**

- **作者**: Arakawa T, et al.

- **摘要**: 采用GSTO1抗體對阿爾茨海默病患者腦組織進(jìn)行免疫組化分析,發(fā)現(xiàn)其在小膠質(zhì)細(xì)胞中異常聚集,可能參與神經(jīng)炎癥和疾病進(jìn)展機(jī)制。

*注:以上文獻(xiàn)信息為示例性質(zhì),具體引用時(shí)需核實(shí)原文準(zhǔn)確性。建議通過PubMed或Web of Science以“GSTO1 antibody”或“GSTO1 immunohistochemistry”等關(guān)鍵詞檢索最新研究。*

       

背景信息

The glutathione S-transferase omega 1 (GSTO1) antibody is a tool used to detect and study the GSTO1 protein, a member of the glutathione S-transferase (GST) superfamily. GSTO1 is distinct from other GST classes due to its unique structural features and enzymatic activities, including deglutathionylation and thioltransferase functions. It localizes primarily in the cytoplasm and mitochondria, playing roles in oxidative stress response, detoxification, and regulation of apoptosis by modulating redox-sensitive signaling pathways. GSTO1 also interacts with interleukin-1β (IL-1β) precursors, influencing inflammatory processes.

Research highlights GSTO1's involvement in diseases such as neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s), cancer, and cardiovascular conditions. Polymorphisms in the GSTO1 gene are linked to altered susceptibility to these diseases. The GSTO1 antibody is crucial for applications like Western blotting, immunohistochemistry, and immunofluorescence to analyze protein expression, localization, and disease-associated changes. Validated antibodies help elucidate GSTO1's role in cellular redox homeostasis, drug metabolism, and pathological mechanisms. Both monoclonal and polyclonal variants are available, with specificity often confirmed via knockout controls. Its utility spans basic research, biomarker discovery, and therapeutic target validation.

       
關(guān)鍵字: GSTO1抗體;GSTO1;GSTO1 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (1年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:1年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
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