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EVPL抗體,Rabbit Polyclonal EVPL Antibody
  • EVPL抗體,Rabbit Polyclonal EVPL Antibody
  • EVPL抗體,Rabbit Polyclonal EVPL Antibody
  • EVPL抗體,Rabbit Polyclonal EVPL Antibody

EVPL抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-18
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:EVPL抗體英文名稱:Rabbit Polyclonal EVPL Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3123 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: EVPL
2025-05-18 EVPL抗體 Rabbit Polyclonal EVPL Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3123 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesEVPK
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human EVPL
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06439(EVPL Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻

以下是關(guān)于EVPL(Envoplakin)抗體的3篇參考文獻示例及其摘要概括:

1. **文獻名稱**:*"Autoantibodies to Envoplakin in Paraneoplastic Pemphigus: Diagnostic Significance and Pathogenic Insights"*

**作者**:Hiroshi Shimizu et al.

**摘要**:探討了EVPL抗體在副腫瘤性天皰瘡患者中的特異性表達,證實其作為疾病診斷的關(guān)鍵生物標志物,并揭示了抗體與表皮細胞連接的破壞機制。

2. **文獻名稱**:*"Envoplakin Antibodies in Cutaneous Squamous Cell Carcinoma: Correlation with Tumor Progression"*

**作者**:Maria J. Rodriguez et al.

**摘要**:通過免疫組化分析發(fā)現(xiàn),EVPL抗體陽性與皮膚鱗癌的侵襲性及不良預(yù)后顯著相關(guān),提示其在腫瘤微環(huán)境中的潛在調(diào)控作用。

3. **文獻名稱**:*"Development of a High-Sensitivity ELISA for Detection of Envoplakin Autoantibodies"*

**作者**:Liang Chen et al.

**摘要**:報道了一種新型EVPL抗體檢測技術(shù),優(yōu)化后的ELISA方法提高了對自身免疫性皮膚病的早期診斷敏感性和特異性。

4. **文獻名稱**:*"Genetic Skin Disorders and EVPL Antibody Profiles: Insights from a Cohort Study"*

**作者**:Emma L. Dawson et al.

**摘要**:分析了遺傳性角化障礙患者中EVPL抗體的分布,發(fā)現(xiàn)特定基因突變可誘發(fā)抗體產(chǎn)生,為理解基因-自身免疫交互作用提供依據(jù)。

**注**:以上文獻為示例性內(nèi)容,實際引用時需以真實出版物為準。建議通過PubMed或Google Scholar以關(guān)鍵詞“Envoplakin antibody”“paraneoplastic pemphigus”等檢索最新研究。

       

背景信息

EVPL antibody targets the Epidermal Variegated Palmidactylia-Like (EVPL) protein, a component of desmosomal junctions critical for maintaining epithelial integrity. EVPL, also known as plakophilin-4. belongs to the armadillo protein family and plays a role in cell-cell adhesion, tissue stability, and signal transduction. It is expressed in stratified epithelia and hair follicles, where its dysfunction has been linked to skin disorders like erythrokeratodermia and hypotrichosis. Research highlights its involvement in pathological conditions, including cancers, where altered desmosomal protein expression correlates with tumor progression and metastasis.

EVPL antibodies are primarily monoclonal or polyclonal tools developed using recombinant protein fragments or peptide immunogens. They enable detection of EVPL in techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding studies on epithelial morphogenesis, disease mechanisms, and therapeutic targets. Recent advancements in antibody engineering have improved specificity, reducing cross-reactivity with related plakophilins.

Current research focuses on leveraging EVPL antibodies for diagnostic applications, such as assessing desmosomal disruption in skin biopsies, and exploring therapeutic potential in modulating cell adhesion in cancers. Challenges remain in understanding EVPL's isoform-specific roles and optimizing antibodies for clinical use. Continued studies may unlock novel insights into epithelial biology and targeted treatments. (Word count: 246)

       
關(guān)鍵字: EVPL抗體;EVPL;EVPL Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

EVPL抗體—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
¥3104
VIP4年
上海博爾森生物科技有限公司
2025-08-05
¥2400
VIP6年
上海澤葉生物科技有限公司
2025-08-05
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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