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ZFYVE27抗體,Rabbit Polyclonal ZFYVE27 Antibody
  • ZFYVE27抗體,Rabbit Polyclonal ZFYVE27 Antibody
  • ZFYVE27抗體,Rabbit Polyclonal ZFYVE27 Antibody
  • ZFYVE27抗體,Rabbit Polyclonal ZFYVE27 Antibody

ZFYVE27抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-16
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ZFYVE27抗體英文名稱:Rabbit Polyclonal ZFYVE27 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2423 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: ZFYVE27
2025-05-16 ZFYVE27抗體 Rabbit Polyclonal ZFYVE27 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2423 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesSPG33; PROTRUDIN
WB Predicted band size46 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human ZFYVE27
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: PC3 and Hela cell lysates, Primary antibody: P03105(ZFYVE27 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P03105(ZFYVE27 Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P03105(ZFYVE27 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

參考文獻

以下是關于ZFYVE27(Protrudin)抗體的參考文獻示例(注:部分內(nèi)容為示例性概括,非真實文獻):

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1. **文獻名稱**:*ZFYVE27/Protrudin regulates neurite outgrowth via vesicular trafficking in hippocampal neurons*

**作者**:Matsuda S., Inoue T.

**摘要**:本研究利用ZFYVE27特異性抗體,通過免疫熒光和Western blot技術,揭示了ZFYVE27在神經(jīng)元內(nèi)體運輸中的作用。實驗表明,ZFYVE27敲除導致軸突生長缺陷,提示其通過調(diào)控Rab11陽性囊泡運輸促進神經(jīng)突起延伸。

2. **文獻名稱**:*Loss of ZFYVE27 function in hereditary spastic paraplegia models disrupts endoplasmic reticulum dynamics*

**作者**:Reid E., Crosby A.H.

**摘要**:通過患者來源的細胞系和ZFYVE27抗體檢測,研究發(fā)現(xiàn)遺傳性痙攣性截癱相關突變導致ZFYVE27蛋白表達異常,內(nèi)質(zhì)網(wǎng)與晚期內(nèi)體膜接觸減少,進而影響長鏈脂肪酸代謝及軸突穩(wěn)態(tài)。

3. **文獻名稱**:*Characterization of a novel monoclonal antibody against human ZFYVE27 for studying cancer cell invasion*

**作者**:Zhou L., Li W.

**摘要**:本文報道了一種高特異性抗ZFYVE27單克隆抗體的開發(fā),并通過免疫共沉淀和質(zhì)譜分析驗證其靶向性。該抗體在乳腺癌細胞中證實ZFYVE27通過調(diào)控MMP分泌促進細胞侵襲。

4. **文獻名稱**:*Protrudin-mediated membrane trafficking promotes myelination in Schwann cells*

**作者**:Jahn R., Deng F.

**摘要**:利用ZFYVE27抗體進行組織染色,發(fā)現(xiàn)其在施萬細胞中富集于內(nèi)體-ERGIC膜結(jié)構(gòu),并通過與KIF5馬達蛋白互導,調(diào)控髓鞘形成相關脂質(zhì)的定向運輸,為脫髓鞘疾病研究提供新機制。

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**說明**:上述文獻為模擬示例,實際研究需通過學術數(shù)據(jù)庫(如PubMed)檢索關鍵詞“ZFYVE27 antibody”“Protrudin antibody”獲取真實文獻。

       

背景信息

The ZFYVE27 antibody is a research tool designed to detect and study the ZFYVE27 protein, also known as Protrudin, encoded by the ZFYVE27 gene. This protein contains a FYVE domain, a zinc finger motif that binds phosphatidylinositol 3-phosphate (PI3P), and plays a role in membrane trafficking, neurite outgrowth, and intracellular vesicle transport. ZFYVE27 is particularly implicated in regulating endoplasmic reticulum (ER)-endosome contact sites, facilitating cargo transfer and maintaining cellular homeostasis. Dysfunction of ZFYVE27 has been linked to hereditary spastic paraplegia (HSP), a neurodegenerative disorder characterized by progressive lower limb spasticity, due to its role in axon elongation and neuronal maintenance.

The ZFYVE27 antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to analyze protein expression, localization, and interactions in various cell types and tissues. It aids in investigating ZFYVE27's involvement in membrane dynamics, autophagy, and neurodegenerative pathways. Researchers also utilize this antibody to explore its interactions with binding partners, such as Rab11 and VAPB, which are critical for ER-endosome tethering. Validated for specificity and sensitivity, the antibody is typically raised in hosts like rabbits or mice, with applications in both basic research and disease model studies. Its development supports ongoing efforts to understand ZFYVE27's mechanistic contributions to neurodegeneration and potential therapeutic targets.

       
關鍵字: ZFYVE27抗體;ZFYVE27;ZFYVE27 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學,細胞生物學 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

ZFYVE27抗體—艾普蒂相關廠家報價

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