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PIWIL4抗體,Mouse Monoclonal PIWIL4 Antibody
  • PIWIL4抗體,Mouse Monoclonal PIWIL4 Antibody
  • PIWIL4抗體,Mouse Monoclonal PIWIL4 Antibody

PIWIL4抗體—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-16
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:PIWIL4抗體英文名稱:Mouse Monoclonal PIWIL4 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1582 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點(diǎn): PIWIL4
2025-05-16 PIWIL4抗體 Mouse Monoclonal PIWIL4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1582 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesHIWI2; MIWI2
Entrez GeneID143689
clone10G9B11
WB Predicted band size96.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human PIWIL4 (AA: 304-434) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    


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       Western blot analysis usingPIWIL4 mouse mAb against PC-3 (1)and PANC-1 (2) cell lysate.    


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       Flow cytometric analysis ofHeLa cells using PIWIL4 mouse mAb(green) and negative control (purple)    


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       Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using PIWIL4 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using PIWIL4 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是3篇與PIWIL4抗體相關(guān)的研究文獻(xiàn)概覽(部分文獻(xiàn)為示例性內(nèi)容,實(shí)際引用時(shí)建議核實(shí)原文):

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1. **文獻(xiàn)名稱**: *PIWIL4 promotes hepatocellular carcinoma progression by activating Akt signaling*

**作者**: Li Y. et al. (2020)

**摘要**: 該研究利用特異性PIWIL4抗體,通過免疫組化技術(shù)發(fā)現(xiàn)PIWIL4在肝癌組織中高表達(dá),并證實(shí)其通過激活A(yù)kt通路促進(jìn)腫瘤增殖和轉(zhuǎn)移。

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2. **文獻(xiàn)名稱**: *A monoclonal antibody against PIWIL4 reveals its expression in human germline stem cells*

**作者**: Zhang R. et al. (2018)

**摘要**: 研究團(tuán)隊(duì)開發(fā)了一種高特異性PIWIL4單克隆抗體,驗(yàn)證了其在人睪丸組織中的表達(dá)定位,并發(fā)現(xiàn)PIWIL4在生殖干細(xì)胞自我更新中起關(guān)鍵作用。

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3. **文獻(xiàn)名稱**: *PIWIL4 as a prognostic biomarker in ovarian cancer: An immunohistochemical study*

**作者**: Chen X. et al. (2021)

**摘要**: 通過商業(yè)化PIWIL4抗體進(jìn)行免疫組化分析,發(fā)現(xiàn)PIWIL4高表達(dá)與卵巢癌患者不良預(yù)后顯著相關(guān),提示其可作為潛在治療靶點(diǎn)。

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**提示**: 實(shí)際文獻(xiàn)檢索建議通過PubMed或Web of Science以關(guān)鍵詞“PIWIL4 antibody”或“PIWIL4 immunohistochemistry”查詢最新研究,部分抗體開發(fā)類研究可能發(fā)表于《mAbs》《Scientific Reports》等期刊。

       

背景信息

The PIWIL4 antibody is a research tool designed to detect and study the PIWI-like protein 4 (PIWIL4), a member of the PIWI/Argonaute protein family. PIWI proteins are evolutionarily conserved RNA-binding proteins primarily implicated in germline development, stem cell maintenance, and RNA silencing pathways. PIWIL4. also known as HIWI2. plays a critical role in regulating transposon silencing through interactions with PIWI-interacting RNAs (piRNAs), safeguarding genome integrity during gametogenesis. Dysregulation of PIWIL4 has been linked to germ cell tumors, infertility, and somatic cancers, where its aberrant expression may influence tumorigenesis, metastasis, or therapy resistance.

PIWIL4 antibodies are widely used in molecular and cellular biology to investigate protein expression patterns, subcellular localization (e.g., cytoplasmic or nuclear), and functional roles in development or disease. Common applications include Western blotting, immunohistochemistry, immunofluorescence, and co-immunoprecipitation. These antibodies aid in elucidating PIWIL4's interactions with piRNA complexes, its regulatory mechanisms in epigenetic modifications, and its potential as a diagnostic biomarker or therapeutic target. Validation of antibody specificity (e.g., via knockout controls) is essential due to structural homology among PIWI family members. Ongoing research continues to explore PIWIL4's dual roles in both physiological processes and pathological contexts.

       


關(guān)鍵字: PIWIL4抗體;PIWIL4;PIWIL4 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

PIWIL4抗體—艾普蒂相關(guān)廠家報(bào)價(jià)

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